...Shane D'Souza; Richard A. Lang ABSTRACT Retinal ganglion cells (RGCs) serve as a crucial communication channel from the retina to the brain. In the adult, these cells receive input from defined sets of presynaptic partners and communicate with postsynaptic brain regions to convey features...

... the expression of a particular bHLH factor influences RPC fate is unclear. Previously, we have shown that Neurod1 inserted into the Atoh7 locus activates the retinal ganglion cell (RGC) program in Atoh7 -expressing RPCs but not in Neurod1 -expressing RPCs, suggesting that Atoh7 -expressing RPCs are not able...

... of retinal neurogenesis. Development 125 , 4821 -4833. Brown, N. L., Patel, S., Brzezinski, J. and Glaser, T. ( 2001 ). Math5 is required for retinal ganglion cell and optic nerve formation. Development 128 , 2497 -2508. Brown, N. L., Dagenais, S. L., Chen, C. M. and Glaser, T. ( 2002...

... for establishing retinal ganglion cell (RGC) fate. We analyzed the retinas of mice in which Math5 was replaced with Neurod1 or Math3 , bHLH genes that are expressed in another RPC and are required to establish amacrine cell fate. In the absence of Math5, Math5 Neurod1-KI was able to specify RGCs, activate RGC...

...Chai-An Mao; Takae Kiyama; Ping Pan; Yasuhide Furuta; Anna-Katerina Hadjantonakis; William H. Klein The mechanisms regulating retinal ganglion cell (RGC) development are crucial for retinogenesis and for the establishment of normal vision. However,these mechanisms are only vaguely understood. RGCs...

... that in the avascular chicken retina, vascular endothelial growth factor(VEGF) secreted by postmitotic neurons acts through the FLK1 receptor present on progenitor cells to influence cell proliferation and commitment. Augmenting VEGF signals increases progenitor cell proliferation and decreases retinal ganglion cell...

..., Brn3a ki functionally restored the normal development and survival of retinal ganglion cells (RGCs) in the absence of Brn3b and fully reinstated the early developmental expression profiles of Brn3b downstream target genes in retina. These results indicate that Brn3 factors are functionally equal...

... hedgehog (Shh) from retinal ganglion cells (RGCs) promotes the development of optic disc and stalk neuroepithelial cells. We demonstrate that RGCs express Shh soon after differentiation, and cells at the optic disc in close proximity to the Shh-expressing RGCs upregulate Hh target genes, which suggests...

...Françoise Trousse; Elisa Martí; Peter Gruss; Miguel Torres; Paola Bovolenta Retinal ganglion cell (RGC) axons grow towards the diencephalic ventral midline during embryogenesis guided by cues whose nature is largely unknown. We provide in vitro and in vivo evidence for a novel role of Sonic...

... that influence both the generation and the maintenance of neurones during development. We show that in the chick embryo, stratified retinal ganglion cells (RGCs) are themselves responsible for providing the signals that control the number of RGCs that are generated, both by inhibiting the generation of new...

...Eric Birgbauer; Chad A. Cowan; David W. Sretavan; Mark Henkemeyer Optic nerve formation requires precise retinal ganglion cell (RGC) axon pathfinding within the retina to the optic disc, the molecular basis of which is not well understood. At CNS targets, interactions between Eph receptor tyrosine...

...Valerie A. Wallace; Martin C. Raff ABSTRACT Retinal ganglion cell (RGC) axons have been shown to stimulate the proliferation of astrocytes in the developing rodent optic nerve, but the signals that mediate this effect have not been identified. The following findings suggest that Sonic hedgehog (Shh...

... and migration (embryonic day 5-7), whereas the latter one cor-responds to the well-documented process of retinal ganglion cell death following tectal innervation (embryonic day 10-14; Rager, G. H. (1980) Adv. Anat. Embryol. Cell Biol . 63, 1-92). In the early period, apoptosis is induced by nerve growth factor...

... for correspondence 30 01 1996 © 1996 by Company of Biologists 1996 retinal ganglion cells ARIA heregulin neu erbB Neuregulins are a class of cell surface and secreted proteins with diverse functions in a variety of different tissues (see Peles and Yarden, 1993 ; Mudge, 1993...

...Masahito Yamagata; Joshua R. Sanes ABSTRACT In diverse vertebrate species, defined subsets of retinal ganglion cells (RGCs, the neurons that project from retina to brain) are distinguishable on the basis of their dendritic morphology, physiological properties, neurotransmitter content and synaptic...

...Charles Straznicky; Mark Chehade ABSTRACT In adult domestic chickens, the neurones in the retinal ganglion cell layer are very unevenly disposed such that there is a sixfold increase in neurone density from the retinal edge to the retinal centre. The formation of the high ganglion-cell-density area...