... into a mouse with microphthalmia, eye size was rescued. To understand the function of these SE modules during human retinal development, we deleted individual modules in human embryonic stem cells and generated retinal organoids. Deleting one module results in small organoids, recapitulating the small-eyed...

...Michael L. Kaufman; Noah B. Goodson; Ko Uoon Park; Michael Schwanke; Emma Office; Sophia R. Schneider; Joy Abraham; Austin Hensley; Kenneth L. Jones; Joseph A. Brzezinski ABSTRACT During retinal development, a large subset of progenitors upregulates the transcription factor Otx2 , which is required...

.... Together, these data represent a valuable resource shedding light on transcription factor sequences and guidance cue dynamics during mouse retinal development. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests...

... forward. Retinal development Stem cell Regenerative medicine Degenerative retinal diseases Macular degeneration Retina pigment epithelial cells New York State Empire Stem Cell Fund C028504 National Eye Institute 10.13039/100000053 R01EY022079 Macula Vision...

... , invagination started at the side opposite the fissure, and fissure formation was coupled with the polarized invagination processes. In vertebrate retinal development, it has been thought that the optic fissure is formed by folding of the ventral retinal epithelium ( Heermann et al., 2015 ); however...

... of Biologists Ltd 2016 Summary: Time-lapse imaging and biochemical studies suggest that Fat3 acts autonomously via Ena/VASP to orient the cytoskeleton in mouse amacrine cell precursors as they migrate and elaborate dendrites. Amacrine cell Retinal development Fat3 Ena/VASP Planar polarity...

...Andrea Barabino; Vicky Plamondon; Mohamed Abdouh; Wassim Chatoo; Anthony Flamier; Roy Hanna; Shufeng Zhou; Noboru Motoyama; Marc Hébert; Joëlle Lavoie; Gilbert Bernier ABSTRACT Retinal development occurs through the sequential but overlapping generation of six types of neuronal cells and one glial...

... development, a complete eye is formed but is subsequently lost. In Astyanax mexicanus , another blind cavefish, eye loss has been attributed to interference during eye field patterning. To address whether similar pathways have been targeted by evolution independently, we investigated the retinal development...

... Competing interests The authors declare no competing financial interests. 18 4 2013 26 9 2013 © 2013. Published by The Company of Biologists Ltd 2013 Cell fate Eye Gsk3β Mitf Optic vesicle patterning Optic cup Retinal development Smad Vsx2 During...

... and neuronal morphogenesis during embryonic and retinal development. Here we show that Abl is required for photoreceptor cell fate maintenance, as Abl mutant photoreceptors lose neuronal markers during late pupal stages but do not re-enter a proliferative state or undergo apoptosis. Failure to maintain...

... autonomous modes of organogenesis and homeostasis. We also attempt to interpret the results of previous in vivo studies of retinal development in light of the self-organising nature of the retina. * Author for correspondence ( [email protected] ) Competing interests statement The authors...

... interests. 4 5 2010 © 2010. 2010 Neurogenesis Retinal development Transcription regulation Medaka The vertebrate retina is a layered structure composed of six neuronal and one glial cell type, which are organised in three cellular layers: the ganglion cell layer, comprising...

[email protected] ) 31 3 2008 © 2008. 2008 LIM-homeodomain POU domain MATH5 ATOH7 POU4F2 RGC Retinal development Transcription factor Owing to its easy accessibility and well-organized laminar structure, the retina has long served as an ideal experimental model for studying...

... types, including horizontal and amacrine cell. Retinal development Basic helix-loop-helix Amacrine cell Horizontal cell Ganglion cell Lineage tracing Ptf1a Foxn4 Progenitor Cell specification © 2006. 2006 30 8 2006 † Present address: Center for Therapeutic...

... by Brachmann and Cagan, 2003 ; Freeman, 1997 ; Vaux and Korsmeyer, 1999 ). Zonula adherens crumbs Notch RhoA (Rho1) Retinal development ©2005. 2005 21 2 2005 * Author for correspondence (e-mail: [email protected] ) ...

...-mail: [email protected] ) 31 8 2001 © 2001. 2001 Optic vesicle Neural retina Retinal pigment epithelium Neural patterning Retinal development Lens differentiation FGF9 Ras Mouse During vertebrate embryogenesis, the neuroectoderm gives rise to a variety of neural and non...

... for correspondence (e-mail: [email protected] ) 11 04 1997 © 1997 by Company of Biologists 1997 mouse retina rod photoreceptors retinal development LIF Müller cells The major classes of cells in the vertebrate neural retina, including photoreceptors, neurons and Müller glial cells...

... in a single row. This reorganisation is a prerequisite for the identification of death candidates. Irregular chiasmC-roughest function in retinal development demonstrates the importance of specific cell contacts for assignment of the apoptotic fate. * Author for correspondence 27 03 1996 ©...

... 1995 by Company of Biologists 1995 integrin α 2 β 1 retinal development collagen receptor chick eye extracellular matrix The development of the central nervous system involves both extrinsic and intrinsic signals which influence neuronal differentiation. The retina is an example...

..., are differentially expressed during chick retinal development. We isolated a cDNA for a novel N-terminal variant of chick TR β (cTR β ) that is predominantly expressed in retinal development. Interestingly, in its N-terminal A/B domain cTR β 2 is 70% homologous to the rat pituitaryspecific TR β . Expression of cTR β...