... by The Company of Biologists Ltd 2024 Summary: This Review provides an overview of the main mechanisms contributing to the Hox spatial-temporal collinearity in vertebrates, from factors triggering Hox initial activation to chromatin topology. Hox Collinearity Development Patterning Regulation...

... Review highlights the novel insights into stem cell regulation, new technologies aiding in discovery and exciting breakthroughs in the field of regenerative medicine that emerged from the meeting. * Author for correspondence ( [email protected] ) Competing interests...

... from diverse tissues via mesenchymal cell-driven condensation . Cell Stem Cell   16 , 556 - 565 . 10.1016/j.stem.2015.03.004 United States Government ( 2009 ). Code of Federal Regulations Title 45, Part 46.101.b.2., https://www.hhs.gov/ohrp/sites/default/files/ohrp/policy...

...) was shown to be a transcriptional product in thousands of human and mouse genes and in hundreds of cases constituted the dominant RNA isoform. Subsequent studies revealed that the expression of circRNAs is developmentally regulated, tissue and cell-type specific, and shared across the eukaryotic tree...

... the specification of the pronephric territory and define its size. This seems to occur, at least in part, through positive regulation of Bmp signalling. Subsequently, Irx genes are required for proper formation of the intermediate tubule. Finally, we find that retinoic acid signalling activates both Irx1 and Irx3...

..., we describe at least two modes of regulating the expression of Ath5 during retinal development. We have found that a proximal cis-regulatory region of the Xenopus Ath5 gene ( Xath5 ) is highly conserved across vertebrate species and is sufficient to drive retinal-specific reporter gene expression...

... it is displaced from its normal position to the C terminus of Engrailed 2, leading to a constitutive blockage of Engrailed 2 intercellular transfer. This indicates that intercellular transfer of Engrailed 2 is a highly regulated process. *Author for correspondence (e-mail: [email protected] ) 30 4...

...Hong Zhang; Scott W. Emmons ABSTRACT We describe the properties of a new gene, sop-3 , that is required for the regulated expression of a C. elegans Hox gene, egl-5 , in a postembryonic neuroectodermal cell lineage. Regulated expression of egl-5 in this cell lineage is necessary for development...

...John F. Rawls; Stephen L. Johnson ABSTRACT Fin regeneration in adult zebrafish is accompanied by reestablishment of the pigment stripes. To understand the mechanisms underlying fin stripe regeneration and regulation of normal melanocyte stripe morphology, we investigated the origins of melanocytes...

.... In the mesenchyme Dlx2 is expressed proximally, whereas in oral epithelium it is expressed distally. Dlx2 has been shown to be involved in the patterning of the murine dentition, since loss of function of Dlx1 and Dlx2 results in early failure of development of upper molar teeth. We have investigated the regulation...

.... ( 1995 ). Expression and regulation of GATA-2 and GATA-3 in hematopoietic and other cell lineages. in . In Biology of Hematopoiesis and Stem Cell Gene Transfer (ed. G. Stamatoyannopoulos ), pp. 15 - 35 . Andover: Intercept Press. Lumsden , A. and Krumlauf , R. ( 1996...

..., the complex spatial pattern of CyIIa expression is completely reproduced by a compact upstream regulatory element <450 bp in length. We found no evidence anywhere in the 4.4 kb sequence examined for negative regulators required to repress ectopic expression. The specific site that mediates CyIIa expression...

...George N. Serbedzija; Jau-Nian Chen; Mark C. Fishman ABSTRACT In many vertebrates, removal of early embryonic heart precursors can be repaired, leaving the heart and embryo without visible deficit. One possibility is that this ‘regulation’ involves a cell fate switch whereby cells, perhaps...

... ‡ Corresponding author (E-mail: [email protected] ) 17 02 1998 18 12 1997 © 1998 by Company of Biologists 1998 Hox genes Regulation Synergism Hindbrain Gene targeting RARE Regional diversity in the vertebrate hindbrain is achieved through a process of segmentation...

... the reconstituted Hensen’s node and, therefore, acts like a Nieuwkoop Center. These findings increase our understanding of the mechanism of notochord reconstitution, provide new information and a novel model system for studying the induction of the organizer and reveal the potential of the epiblast to regulate its...

... unilaterally by micro-surgery. Of the embryos that survived, about 35% exhibited regulative regeneration, wherein the missing hemi-rhombomere was reconstituted to normal size and morphology through compensatory proliferation and migration from adjacent tissue. The capacity for regener-ation depended...

... that poly-homeotic activation in germ-band-elongated embryos could be mediated by Engrailed-binding to these sites. * Author for correspondence 06 03 1995 © 1995 by Company of Biologists 1995 Drosophila engrailed polyhomeotic target genes regulation Proteins...

... bordering the ablated region demonstrate that cells at the same axial level, in the lateral and ventral neural tube, regulate to reconstitute a population of neural crest cells. These cells emigrate from the neural tube, migrate along normal pathways according to their axial level of origin and appear...

... in this respect, also fails to fulfil some of the predictions of the autoregulatory model ( Katz et al., 1990 ). Although this yeast does down-regulate tubulin accumulation in response to increased gene dosage, there is no corresponding up-regulatory response when gene dosage is decreased. The relevance...

... that requires the activity of other segment polarity genes including patched ( ptc ) and hedgehog ( hh ). Here we present further evidence that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes. We also show...