... Branching morphogenesis Organ culture Organoid Receptor tyrosine kinase The receptor tyrosine kinase Ret plays a major role in the formation and branching morphogenesis of the ureteric bud (UB), a tubular epithelial tree that gives rise to the collecting duct system during kidney development...

... and lymphatic vessel development and pathology. VEGF Receptor tyrosine kinase Vessels Jane ja Aatos Erkon Säätiö 10.13039/501100004012 European Research Council 10.13039/100010663 743155 Jenny ja Antti Wihurin Rahasto 10.13039/501100004022 Suomen Akatemia...

... ossification Receptor tyrosine kinase Neural crest Mesoderm Bone formation is a complex process in which mesenchymal cells become osteoblasts and deposit bone matrix. There are generally two pathways to form bone. The mesenchymal cells may first form a cartilaginous template that is later replaced...

...Smita Amarnath; Leslie M. Stevens; David S. Stein Formation of the Drosophila embryonic termini is controlled by the localized activation of the receptor tyrosine kinase Torso. Both Torso and Torso's presumed ligand, Trunk, are expressed uniformly in the early embryo. Polar activation of Torso...

... to those seen with other signaling mutants, such as in the JNK pathway, and we demonstrate that JNK signaling is not perturbed by altering Pvr receptor tyrosine kinase activity. Rather, modulation of Pvr levels in the ectoderm has an impact on PIP3 membrane accumulation, consistent with a link to PI3K...

...Yingjie Liu; Nibedita Chattopadhyay; Shan Qin; Charles Szekeres; Tetyana Vasylyeva; Zhen X. Mahoney; Mary Taglienti; Carlton M. Bates; Harold A. Chapman; Jeffrey H. Miner; Jordan A. Kreidberg Integrin receptors for the extracellular matrix and receptor tyrosine kinase growth factor receptors...

... endothelial-to-mesenchymal transition and neural crest cell recruitment into the OFT cushions, resulting in OFT septation defects. These results provide new insight into the signaling molecules downstream of FGF receptor tyrosine kinases in cardiac progenitors. * Author for correspondence (e-mail: fwang...

... known as linotte ) receptor tyrosine kinase as an essential component of adult MB development. Here we show, using MARCM clones, a non-cell-autonomous requirement for the DRL receptor in MB development. This result is in accordance with the pattern of DRL expression, which occurs throughout development...

... activities by activating diverse isotypes of FGF receptor tyrosine kinases (FGFRs). Among the FGFs, FGF7 and FGF10 have been implicated in the regulation of prostate development and prostate tissue homeostasis by signaling through the FGFR2 isoform. Using conditional gene ablation with the Cre-LoxP system...

... to Receptor Tyrosine Kinase signaling by outcompeting POINTED for access to target gene promoters. We demonstrate that the molecular mechanism underlying downregulation of YAN involves CRM1-mediated nuclear export and define a novel role in this context for MAE, a co-factor previously implicated...

...Ruth Herbst; Ekaterina Avetisova; Steven J. Burden Mice lacking Musk, a muscle-specific receptor tyrosine kinase that is activated by agrin, fail to form neuromuscular synapses and consequently die at birth because of their failure to move or breathe. We produced mice that express a chimeric...

...-specific LIM homeobox gene Xlim-1 in Xenopus animal caps, we isolated the receptor tyrosine kinase Xror2. Xror2 is expressed initially in the dorsal marginal zone, then in the notochord and the neuroectoderm posterior to the midbrain-hindbrain boundary. mRNA injection experiments revealed...

...Rachel K. Smith; Pamela M. Carroll; John D. Allard; Michael A. Simon The receptor tyrosine kinases Sevenless (SEV) and the Epidermal growth factor receptor (EGFR) are required for the proper development of the Drosophila eye. The protein tyrosine phosphatase Corkscrew (CSW) is a common component...

... development. The EphA4 receptor tyrosine kinase and its ligand, ephrin-A5, are expressed by muscle precursor cells and forelimb mesoderm in unique spatiotemporal patterns during the period when muscle precursors delaminate from the dermomyotome and migrate into the limb. To test the function of EphA4/ephrin...

... © 2000 by Company of Biologists 2000 Receptor tyrosine kinase Basic-helix-loop-helix-leucine zipper protein Dautochrome tautomerase pMel 17/Silver Tyrosinase-related protein-1 Tyrosinase Cholera toxin Neural crest cell culture The development of distinct cell lineages from...

...Makoto Koga; Masaya Take-uchi; Tatsuji Tameishi; Yasumi Ohshima KIN-8 in C. elegans is highly homologous to human ROR- 1 and 2 receptor tyrosine kinases of unknown functions. These kinases belong to a new subfamily related to the Trk subfamily. A kin-8 promoter:: gfp fusion gene was expressed...

...Mira C. Puri; Juha Partanen; Janet Rossant; Alan Bernstein TEK (TIE2) and TIE (TIE1) are structurally related receptor tyrosine kinases expressed in endothelial cells and their precursors. Genetic studies in the mouse have revealed essential functions of both receptors in angiogenic expansion...

... inhibit other receptor tyrosine kinase (RTK) signaling pathways, namely the Heartless FGF receptor and the EGF receptor. Similarly, in wing imaginal discs, ectopic Sprouty abolishes activated MAP kinase induced by the EGF receptor pathway. Sprouty expression is induced by the EGFR pathway in some...

...Stavros Taraviras; Camelia V. Marcos-Gutierrez; Pascale Durbec; Harsha Jani; Maria Grigoriou; Madhu Sukumaran; Li-Chong Wang; Mary Hynes; Geoffrey Raisman; Vassilis Pachnis ABSTRACT RET is a member of the receptor tyrosine kinase (RTK) superfamily, which can transduce signalling by glial cell line...

[email protected] ) 02 10 1998 12 11 1998 © 1998 by Company of Biologists 1998 Ras Raf Receptor tyrosine kinase Drosophila melanogaster Signaling through the evolutionarily conserved cassette of molecules including p21 Ras (Ras), Raf and the mitogen-activated protein kinase...