... in the embryonic epidermis of Drosophila . Transcriptional profiling and in situ hybridisation show that JNK signalling is upregulated in mutants lacking Crumbs or other apical determinants. This leads to transcriptional activation of the pro-apoptotic gene reaper and to apoptosis. Suppression of JNK signalling...

... normal death. Expression of reaper in vCrz neurons and suppression of vCrz-cell death in a reaper -null mutant suggest that reaper functions are required for the death,while no apparent role was found for hid or grim as a death promoter. Our data further suggest that diap1 does not play a role...

... in posterior segments prevents pioneer neuron death postmitotically and cell-autonomously by repressing the RHG-motif cell death activators reaper and grim . Our results identify the first clear case of a cell-autonomous and anti-apoptotic role for a Hox gene in vivo. In addition, they provide a novel...

... involution defective,grim and reaper , which are required for ommatidial elimination. We estimate that approximately 6-8% of the total photoreceptor pool in each eye is removed by this mechanism. In addition, we show that the retinal apoptosis previously reported in apc1 mutants occurs at the same time...

... that sage RNAi embryos have a phenotype similar to sens and that sage is necessary to maintain expression of sens in the embryonic salivary glands. Furthermore, we show that in the salivary glands, sens acts as an anti-apoptotic protein by repressing reaper and possibly hid . * Author...

... of the caspase inhibitor p35 or removal of the pro-apoptotic genes reaper, hid and grim ,showing that the glial cell undergoes apoptosis. Moreover, it seems that fragments are eliminated from the epithelium by mobile macrophages. Forcing survival of the glial cells induces precocious axonal outgrowth but does...

...Christian Peterson; Ginger E. Carney; Barbara J. Taylor; Kristin White Developmentally regulated apoptosis in Drosophila requires the activity of the reaper ( rpr ), grim and head involution defective ( hid ) genes. The expression of these genes is differentially regulated, suggesting...

... of these tissues can be inhibited by ectopic expression of the baculovirus antiapoptotic protein p35, implicating a role for caspases in the death response. Coordinate stage-specific induction of the Drosophila death genes reaper ( rpr ) and head involution defective ( hid ) immediately precedes the destruction...

... axon tracts. Glial apoptosis is blocked in embryos deficient for reaper , where greater than wild-type numbers of midline glia (MG) are present after stage 12. Quantitative studies revealed that MG death followed a consistent temporal pattern during embryogenesis. Apoptotic MG were expelled from...