... specialized functions. Among the differentiated trophoblast cell lineages are invasive trophoblast cells, which exit the placenta and invade the uterus, where they restructure the uterine parenchyma and facilitate remodeling of uterine spiral arteries. The rat exhibits deep intrauterine trophoblast cell...

...Ha T. H. Vu; Regan L. Scott; Khursheed Iqbal; Michael J. Soares; Geetu Tuteja ABSTRACT The invasive trophoblast cell lineages in rat and human share crucial responsibilities in establishing the uterine-placental interface of the hemochorial placenta. These observations have led to the rat becoming...

... development and disease. Previously, our group developed methods to produce prostate organoids using induced pluripotent stem cells (iPSCs). Here, we show that human iPSCs can be differentiated into prostate organoids using neonatal rat seminal vesicle mesenchyme in vitro . The organoids can be used to study...

... reprogramming is sensitive to the environment, which could impair the establishment of an optimal state of the gamete epigenome, hence proper embryo development. Yet, we lack a comprehensive understanding of DNAme dynamics during spermatogenesis, especially in rats, the model of choice for toxicological studies...

... to exit the placenta and invade into the uterus where they restructure the vasculature. Invasive trophoblast cells arise from a well-defined compartment within the placenta, referred to as the junctional zone in rat and the extravillous trophoblast cell column in human. In this study, we investigated...

... Nkx2-2 and Skor2, which are co-expressed in a restricted group of post-mitotic GABAergic precursors in the MRF. Both Gata2 and Nkx2-2 function is required for Skor2 expression in GABAergic precursors. In the adult mouse and rat midbrain, Nkx2-2 -and Skor2 -expressing GABAergic neurons locate...

...-gastrulating embryos in mammals, and subsequently migrate towards gonads to mature into functional gametes. Here, we investigated PGC development in rats, by genetically modifying Prdm14 , a unique marker and an essential PGC transcriptional regulator. We trace PGC development in rats, for the first time, from...

... of GDNF and GFRα1 is required for proper development of hippocampal dendritic arbors and spine maturation through NCAM signaling. GDNF Dendrite complexity Dendritic spines Structural plasticity Hippocampus NCAM Mouse Rat Agencia Nacional de Promoción Científica y Tecnológica...

... induce death of sensory neurons in vitro . The extent to which Sema3A regulates developmental cell death in vivo , however, is debated. We show that in compartmentalized cultures of rat sympathetic neurons, a Sema3A-initiated apoptosis signal is retrogradely transported from axon terminals to cell bodies...

... experiments using postnatal or adult SVZ progenitors reveal key differences in the connective properties of the neurons generated. Adult neurogenesis Synaptic development Fate determination Subventricular zone Rat New neurons are continuously added to the adult mammalian brain. The most...

.../nprot.2007.104 Gomes , F. L. A. F. , Zhang , G. , Carbonell , F. , Correa , J. A. , Harris , W. A. , Simons , B. D. and Cayouette , M. ( 2011 ). Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate...

... for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 2 8 2012 © 2012. 2012 Pancortin Olfactomedin Noelin APP Migration Mouse Rat Migration of neuronal precursor cells in the developing cerebral...

... of Vangl2 expression and shows a strong enrichment of Vangl2 on the SC side. Asterisks indicate Vangl2 enrichment in SCs. D is the same image as in C after 3D deconvolution. ( E-H ′) Surface view projection (Proj XY), single plane view (single XY) and z -stack series (XZ) of the organ of Corti from rat...

... 2012. Cdh1-APC Smurf1 Axon growth Myelin Ubiquitylation Mouse Rat Axon growth is a crucial process in the developing nervous system. It is controlled by a large number of extrinsic regulatory events, which trigger signaling cascades that involve small GTPase-controlled...

... ) * These authors contributed equally to this work Competing interests statement The authors declare no competing financial interests. 18 6 2012 © 2012. Astrocyte fate Oligodendroglial differentiation Multiple sclerosis Regeneration Spinal cord injury Rat Cdkn1c...

... determinants for activity-dependent dendritic growth in a cell type-specific and cell compartment-specific manner. In rodents, the contribution of AMPARs has been studied in spinal cord motoneurons. Rat motoneurons strongly express the AMPAR subunit GluA1(Q)-flip, which controls dendritic complexity largely...

... a method for long-term videomicroscopy to follow the lineages of rat perinatal RPCs cultured at clonal density. In such cultures, cell-cell interactions between two different clones are eliminated and the extracellular environment is kept constant, allowing us to study the cell-intrinsic potential...

...Harry G. Leitch; Kate Blair; William Mansfield; Harold Ayetey; Peter Humphreys; Jennifer Nichols; M. Azim Surani; Austin Smith Mouse and rat embryonic stem cells can be sustained in defined medium by dual inhibition (2i) of the mitogen-activated protein kinase (Erk1/2) cascade and of glycogen...

.... These essential steps in oligodendroglial maturation facilitate the detection of target axons, a key step towards myelination. Sprague Dawley rat pups and pregnant BALB/c mice were obtained from Charles River Canada (Montreal, Quebec, Canada). Ntn1 -/+ and Dcc -/+ mice were obtained from Marc Tessier...

... and tissue functions of early embryonic laminins and netrins. Curr. Opin. Cell Biol. 16 , 572 -579. Axon guidance DCC ROCK PRK C3 Y27632 Regeneration Growth cone Rho GTPases Rat During development, axons are directed to their targets along defined pathways by extracellular cues...