... of shoot meristems. TFL1 expression is dynamic, being found in all shoot meristems, but not in floral meristems, with the level and distribution changing throughout development. Using a variety of experimental approaches we have analysed the TFL1 promoter to elucidate its functional structure. TFL1...

...Omar S. Akbari; Esther Bae; Holly Johnsen; Alfred Villaluz; Debbie Wong; Robert A. Drewell A key question in our understanding of the cis-regulation of gene expression during embryonic development has been the molecular mechanism that directs enhancers to specific promoters within a gene complex...

... consequence of evolutionary changes in the Endo16 promoter of sea urchins. The Endo16 gene encodes a large extracellular protein that is expressed in the endoderm and may play a role in cell adhesion. Its promoter has been characterized in exceptional detail in the purple sea urchin, Strongylocentrotus...

.... * Author for correspondence (e-mail: [email protected] ) 13 06 2000 09 08 2000 © 2000 by Company of Biologists 2000 TrkA Neurotrophins Enhancer Promoter Transgenic Mouse Neural development is controlled by accurate temporal and spatial gene expression. Among...

...Jumin Zhou; Hilary Ashe; Christian Burks; Michael Levine ABSTRACT Genetic studies have identified an unusual transvection process in the Abdominal-B (Abd-B) locus of Drosophila . In some cases distal infraabdominal (iab) regulatory domains continue to activate the Abd-B promoter even when...

...; later, continuous exposure to higher extracellular cAMP concentrations downregulates early gene expression and promotes cytodifferentiation and cell-specific gene expression. The cAMP receptor 1 gene CAR1 has two promoters that are differentially responsive to these extracellular cAMP stimuli. The early...

... and the transcriptional activity of its promoter in cultured smooth muscle cells in vitro and in transgenic mice. In the transgenic animals, promoter constructs ranging in length from 445 to 2126 bp directed reporter expression initially in the heart and the somites of embryos and subsequently in the arteries...

... of scrt expression in postmitotic PNS neurons. * Author for correspondence 31 07 1995 © 1995 by Company of Biologists 1995 deadpan ( dpn ) scratch ( scrt ) snail ( sna ) pan-neural gene Drosophila neurogenesis promoter gene expression...

... of transgene expression are reflected in the extent of CpG demethylation of both MLC1 promoter and MLC enhancer sequences. Variations in reporter gene expression can be reconstituted by in vitro methylation of specific CpGs in transfected MLC-CAT DNA. As the MLC-CAT transgene is activated during embryogenesis...

..., very little is known about the molecular mechanisms that regulate endothelial cell differentiation. We report the first vascular endothelial cell lineage-specific (including angioblastic precursor cells) 1.2 kb promoter in transgenic mice. Moreover, deletion analysis of this promoter region...

... addressed here whether or not the biallelic expression patterns that can be seen during postnatal human liver development reflected a coordinated change in the activities of the four promoters of human IGF2 . We show here that the P2, P3 and P4 promoters, but not the P1 promoter, display monoallelic...

...Stephen Small; David N. Arnosti; Michael Levine ABSTRACT The even-skipped ( eve ) promoter contains a series of enhancers that control the expression of different seg-mentation stripes in the Drosophila embryo. The stripe 3 enhancer is located 1.7 kb upstream of the stripe 2 enhancer. Here we...

... to this problem is to identify regions of the nAChR genes that mediate electrical regulation. Here we report results from such a study of the nAChR δ-subunit gene. We cloned the rat δ-subunit promoter region and created an expression vector in which this DNA controlled the expression of a down-stream luciferase...

...George R. Riley; Erik M. Jorgensen; Robert K. Baker; Richard L. Garber To understand the nature of the regulatory signals impinging on the second promoter of the Antennapedia gene (Antp P2), analysis of its expression in mutants and in inhibitory drug injected embryos has been carried out...