...Hang-Shiang Jiang; Piya Ghose; Hsiao-Fen Han; Yun-Zhe Wu; Ya-Yin Tsai; Huang-Chin Lin; Wei-Chin Tseng; Jui-Ching Wu; Shai Shaham; Yi-Chun Wu ABSTRACT Programmed cell death (PCD) is a common cell fate in metazoan development. PCD effectors are extensively studied, but how they are temporally...

... underlying their female-specific generation. We demonstrate that programmed cell death (PCD) eliminates FS-Ilp7 motoneurons in males, and that this requires male-specific splicing of the sex-determination gene fruitless ( fru ) into the Fru MC isoform. However, in females, fru alleles that only generate Fru...

... roots. Consequently, an enhanced phosphoinositide-mediated vacuolar biogenesis correlates with premature programmed cell death (PCD) and secondary cell wall elaboration in xylem cells. By contrast, vacuolar fusion events in protophloem cells trigger the abnormal formation of big vacuoles, preventing...

...Idit Eshkar-Oren; Sharon Krief; Napoleone Ferrara; Alison M. Elliott; Elazar Zelzer Blood vessels serve as key regulators of organogenesis by providing oxygen, nutrients and molecular signals. During limb development, programmed cell death (PCD) contributes to separation of the digits...

... ) Competing interests The authors declare no competing financial interests. 24 3 2014 12 5 2014 © 2014. Published by The Company of Biologists Ltd 2014 Asymmetric cell division TOE-2 Apoptosis Programmed cell death Cell fate Neuroblast Cysteine proteases, called...

... product of the gene doublesex promotes programmed cell death of these neuroblasts in females, and is needed for their survival, but not proliferation, in males. These data establish the terminal neuromeres as a model for further investigations into the mechanisms controlling segment- and sex-specific...

.... * Author for correspondence ( [email protected] ) Competing interests statement 3 11 2010 © 2011. Drosophila Oogenesis Programmed cell death Mitochondria Bcl-2 Autophagy Apoptosis Caspase Mitochondrial fission and fusion In many organisms, cell...

... to limb morphogenesis( Fig. 10B ). * Author for correspondence( [email protected] ) 2 9 2009 © 2009. 2009 Limb Programmed cell death Apoptosis Morphogenesis CD1 Mouse Chick Bmp Interdigital cell death (ICD) is a morphogenetic event associated with digit separation...

..., but its molecular mechanism remains conjectural. Here we report that genetic ablation of the corpus allatum cells of the Drosophila ring gland (the JH source) resulted in JH deficiency, pupal lethality and precocious and enhanced programmed cell death (PCD) of the larval fat body. In the fat body...

... ) 30 10 2008 © 2008. 2008 Ventral horn Spinal cord Apoptosis Synapse formation Interneurons Programmed cell death In the embryonic central nervous system (CNS), there is a vast overproduction of neurons, with 50% or more undergoing apoptosis during the developmental period...

... apoptotic GWs in T1 and T2 in 21.9% of analyzed hs( n =64, Fig. 3H ). Moreover, GW apoptosis was increased in T3 and in the abdominal segments( Table 1 ). We conclude that Ubx is required in GW at a late developmental stage to activate programmed cell death. We were not able to analyze NB2-4t...

...Yukiko Yamada; Keri D. Davis; Clark R. Coffman Primordial germ cell development uses programmed cell death to remove abnormal, misplaced or excess cells. Precise control of this process is essential to maintain the continuity and integrity of the germline, and to prevent germ cells from colonizing...

... and its disposal capability are on hand when cell death occurs. † Author for correspondence (e-mail: [email protected] ) * Present address: Regeneron Pharmaceuticals, Tarrytown, NY, USA 23 9 2007 © 2007. 2007 Macrophage Angiopoietin Wnt Programmed cell death...

...Sangeeta Pajni-Underwood; Catherine P. Wilson; Cindy Elder; Yuji Mishina; Mark Lewandoski In vertebrate limbs that lack webbing, the embryonic interdigit region is removed by programmed cell death (PCD). Established models suggest that bone morphogenetic proteins (BMPs) directly trigger such PCD...

...Ana Rogulja-Ortmann; Karin Lüer; Janina Seibert; Christof Rickert; Gerhard M. Technau Although programmed cell death (PCD) plays a crucial role throughout Drosophila CNS development, its pattern and incidence remain largely uninvestigated. We provide here a detailed analysis of the occurrence...

... labial Neuroblast Programmed cell death In Drosophila , molecular genetic studies have identified genetic cascades that pattern and specify the embryonic ventral nerve cord (VNC) along the anteroposterior (AP) and dorsoventral (DV) axes. These studies show that segment polarity gene activity...

... of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-2822, USA 16 5 2006 © 2006. 2006 Asymmetric cell division Neuroblast MELK PAR-1 PIG-1 HAM-1 Cell polarity Cell fate Programmed cell death Apoptosis Much of metazoan cellular diversity...

...Youn-Jeong Choi; Gyunghee Lee; Jae H. Park The molecular basis of programmed cell death (PCD) of neurons during early metamorphic development of the central nervous system (CNS) in Drosophila melanogaster are largely unknown, in part owing to the lack of appropriate model systems. Here, we provide...

...Huarui Liu; Tamara J. Strauss; Malia B. Potts; Scott Cameron Hox genes are crucial determinants of cell fates and of body morphology of animals; mutations affecting these genes result in abnormal patterns of programmed cell death. How Hox genes regulate programmed cell death is an important...

...Ken-ichi Kimura; Akitoshi Kodama; Yosihiro Hayasaka; Takumi Ohta At the last step of metamorphosis in Drosophila , the wing epidermal cells are removed by programmed cell death during the wing spreading behavior after eclosion. The cell death was accompanied by DNA fragmentation demonstrated...