...Aihua Mao; Zhuyun Li; Guozhu Ning; Zhengrong Zhou; Chiju Wei; Jianchao Li; Xinyu He; Qiang Wang ABSTRACT Primitive erythropoiesis serves a vital role in embryonic development, generating primitive red blood cells responsible for transportation of oxygen throughout the body. Although diverse niche...

...-loop-helix family of transcription factors that are co-expressed in the erythroid lineage. Previous studies have suggested that Scl is essential for primitive erythropoiesis. However, analysis of single-cell RNA-seq data of early embryos showed that primitive erythroid cells express both Scl and Lyl1...

... at this stage appears to be mediated by the transient expression of Numb in the hemangioblast-derived blast cell colonies. Activation of the Notch pathway was found to inhibit primitive erythropoiesis efficiently through the upregulation of inhibitors of the Wnt pathway. Together, these findings demonstrate...

...-mail: [email protected] 12 6 2007 © 2007. 2007 ES cells Endoglin Hemangioblast Primitive erythropoiesis Mouse Endoglin (ENG) is an accessory receptor for several growth factors of the transforming growth factor-beta (TGF-β) superfamily, including TGF-β 1 , TGF-β 3...

... © 2004. 2004 VEGF SCL TAL1 Primitive erythropoiesis Hematopoiesis ES cell differentiation Mouse Normal development is determined by interactions between a cell and its environment, and by the expression of tissue-specific genes, which allow the control of cell growth, survival...

... of erythropoietin to the culture medium enhanced the production of both embryonic and adult globin chains. The addition of interleukin-3 also enhanced the production of embryonic globin chains, but not the production of adult globin chains. These results indicated that primitive erythropoiesis of PCC3/A/1...