... in a population leads to the self-organized differentiation of stable ratios of cell types. FGF signaling Embryonic stem cells Preimplantation development Primitive endoderm Epiblast Dynamical system Mouse Max Planck Society http://dx.doi.org/10.13039/501100004189...

... homeobox gene that is expressed almost exclusively in human embryos during preimplantation development. We previously identified a novel transcription start site for the predicted human LEUTX gene based on the transcriptional analysis of human preimplantation embryos. The novel variant encodes a protein...

... and extracellular signaling during fate decisions in ESCs. Embryonic stem cells GATA factor Cell fate decision Dynamic systems Live cell imaging Preimplantation development To ensure the faithful development of multicellular organisms, cell fate decisions in populations of undifferentiated cells...

..., the subsequent cleavage stages of embryogenesis and the initial establishment of embryonic cell lineages. Recent studies in mice have yielded new findings on the role of maternally provided proteins and multi-component complexes in preimplantation development. Nevertheless, significant gaps remain in our...

... that promote their development and survival. In other cells, activation of class I phosphoinositide 3-kinase (PI3K) is a universal mechanism to promote cell proliferation and survival. Here, we examined whether PI3K is intrinsically activated during preimplantation development. Using GFP-tagged pleckstrin...

...Momoko Maekawa; Takuya Yamamoto; Michiaki Kohno; Masatoshi Takeichi; Eisuke Nishida Preimplantation development is a crucial step for successful implantation and pregnancy. Although both compaction and blastocyst formation have been extensively studied, mechanisms regulating the early cell division...

... embryos. Hsp70 . 1 GAGA factor Sp1 HSF1 Preimplantation development Zygotic transcription Mouse In the mouse, new embryonic transcription appears after fertilization during the S phase of the first cell cycle in the male pronucleus, while the female pronucleus is largely repressed...

... around 540 U ml −1 colony stimulating factor (=918 Stanley units ml −1 ), and the cytokine can produce the same effects even if it is present in the medium for only part of the culture period. This in vitro stimulation of preimplantation development with macrophage colony stimulating factor is compatible...

...-related expression and cellular localization of GLUTl, 2 and 4. The Western blot results demonstrate that GLUTl is detectable in the oocyte and throughout preimplantation development. GLUT2 isoforms were not detectable until the blastocyst stage, while the GLUT4 isoform was undetectable in the oocyte...

... with their development. However, there is an alternative possibility, which is to analyse different mutations that perturb in one way or another normal preimplantation development. Several of these have been phenotypically described and studied to various extents (reviewed in Magnuson, 1986 ). Here we describe one...

...Jan Tesařík ABSTRACT Considerable evidence indicates that the first phenotypical diversification of embryonic cells during mammalian preimplantation development is achieved in two successive steps: (i) generation of cell asymmetry and (ii) unequal cell division. This paper shows...