... attributed. Summary:   Admp is an upstream regulator of tail bending in the chordate Ciona tailbud embryo, determining tissue polarity of the ventral midline epidermis by localizing phosphorylated myosin. Tunicate Tail bending Intercalation Polarity Boat cell Embryo shape Japan...

.../S1534-5807(02)00318-0 Bertocchini , F. and Stern , C. D. ( 2012 ). Gata2 provides an early anterior bias and uncovers a global positioning system for polarity in the amniote embryo . Development 139 , 4232 - 4238 . 10.1242/dev.081901 Bertocchini , F. , Skromne , I...

... Intestine Microvilli Polarity Horizon 2020 http://dx.doi.org/10.13039/100010661 Marie Sklodowska-Curie Actions 844070 Université de Rennes 1 http://dx.doi.org/10.13039/501100007525 17CQ436-S0 Ligue Contre le Cancer http://dx.doi.org/10.13039/501100004099...

.... The EGF receptor in the nearest VPC sequesters the limiting EGF amounts released by the AC to prevent EGF from spreading to distal VPCs. Here, we show that not only EGFR localization in the VPCs but also EGF polarity in the AC is necessary for robust fate specification. The AC secretes EGF...

... in the regulation of cell migration (e.g. Moore et al., 2013 ; Nishimura and Kaibuchi, 2007 ; Pegtel et al., 2007 ). Thus, one could suggest that overexpressing Par3 might compensate for the lack of MMP14 by promoting delamination independently of its effect on cell polarity. To circumvent this, we attempted...

..., the ubiquitous overexpression may not be high enough to completely erase the endogenous asymmetry of Wnt expression. Another possibility is that another cue acts in parallel to Wnt in the polarization along the anteroposterior axis, such as other chemical or mechanical cues. Finally, it is also possible...

...Cristiano Lucci; Raquel Mesquita-Ribeiro; Alex Rathbone; Federico Dajas-Bailador ABSTRACT Both the establishment of neuronal polarity and axonal growth are crucial steps in the development of the nervous system. The local translation of mRNAs in the axon provides precise regulation of protein...

... polarisation, as both follicle and stalk cells localise polarity factors correctly, despite being mispositioned. Instead, loss of integrins causes pre-follicle cells to constrict basally, detach from the basement membrane and become internalised. Thus, integrin function is dispensable for pre-follicle cell...

...Dianna J. Prince; Jason R. Jessen ABSTRACT Lateral zebrafish hypoblast cells initiate dorsal convergence near mid-gastrulation and exhibit non-polarized morphologies, limited cell-cell contact and indirect migration trajectories. By late gastrulation, mesodermal cells become packed as they engage...

...Aurélien Bidaud-Meynard; Ophélie Nicolle; Markus Heck; Yann Le Cunff; Grégoire Michaux ABSTRACT Intestine function relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border at their luminal pole. Combining a genetic RNA interference (RNAi...

...Andrew W. Folkmann; Geraldine Seydoux ABSTRACT The MARK/PAR-1 family of kinases are conserved regulators of cell polarity that share a conserved C-terminal kinase-associated domain (KA1). Localization of MARK/PAR-1 kinases to specific regions of the cell cortex is a hallmark of polarized cells...

...Anna M. Love; Dianna J. Prince; Jason R. Jessen ABSTRACT During zebrafish gastrulation the planar cell polarity (PCP) protein Vang-like 2 (Vangl2) regulates the polarization of cells that are engaged in directed migration. However, it is unclear whether Vangl2 influences membrane-protrusive...

... reduction of lung size owing to an early arrest of branching morphogenesis. This growth defect is accompanied by abnormalities in epithelial cell polarity, cell division plane and extracellular matrix deposition, as well as precocious and increased expression of markers for type 1 alveolar epithelial cells...

... cells to polarized and tremendously ramified cells. Connexin 30, an astroglial gap-junction channel-forming protein expressed postnatally, regulates in situ the extension and ramification of astroglial processes. However, the involvement of connexin 30 in astroglial polarization, which is known...

...Teresa T. Bonello; Kia Z. Perez-Vale; Kaelyn D. Sumigray; Mark Peifer ABSTRACT Epithelial apical-basal polarity drives assembly and function of most animal tissues. Polarity initiation requires cell-cell adherens junction assembly at the apical-basolateral boundary. Defining the mechanisms...

...Charles F. Lang; Edwin Munro PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They function throughout development and across the metazoa to regulate cell polarity. In recent...

... developing nephron tubules reveals that cell division is not oriented in the longitudinal (or planar-polarized) axis. However, cell division is oriented perpendicular to the apical-basal axis. Absence of afadin in vivo leads to misorientation of apical-basal cell division in nephron tubules. Together...

... the Shh signaling response, causing cell cycle exit and differentiation. We tested this hypothesis using genetic and pharmacological manipulation, gene expression analysis and time-lapse imaging of zebrafish embryos. Blocking the function of miR-219, a microRNA that downregulates apical Par polarity...

... (PIs), also exert regulatory effects. Indeed, emerging evidence indicates that PIs play crucial roles in controlling polarity and growth in plants. Here, I highlight the key roles of PIs as important regulatory membrane lipids in plant development and function. The author apologizes to all authors...

... mammary gland, Blimp1 marks a rare progenitor population, and is required for cell proliferation and polarity as well as efficient milk production. Blimp1 Prdm1 Transcriptional repressor Mammary gland morphogenesis Luminal progenitors Polarity Lumen formation 3D culture Mouse...