.... , Belo , J. A. , Sasaki , H. , et al. ( 2012 ). Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2 . Science   338 , 226 - 231 . 10.1126/science.1222538 Funding M.B. was funded by the Deutsche Forschungsgemeinschaft (BL285/9-2). J.K...

... calmodulin-dependent protein kinase. Prolonged Ca 2+ stimulation converts CaMK-II into an activated state that, in the zebrafish, is detected in the forebrain, ear and kidney. Autosomal dominant polycystic kidney disease has been linked to mutations in the Ca 2+ -conducting TRP family member PKD2...

... of which display defects in organ positioning that resemble human heterotaxia, as well as abnormalities in asymmetric gene expression in the lateral plate mesoderm (LPM) and dorsal diencephalon of the brain. Interestingly, mouse and zebrafish pkd2 -/- mutants have disparate effects on nodal expression...