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Keywords: piwi
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Journal Articles
In collection:
Human development
Journal: Development
Development (2019) 146 (12): dev171157.
Published: 01 February 2019
... to epigenetic silencing of L1 via H3K9me3. In germ cells, the activity of TEs is mollified by an evolutionarily conserved genome defense system made up of PIWI proteins and PIWI-interacting RNAs (piRNAs) collectively called the PIWI-piRNA pathway. piRNAs that are 26-32 nt complex with PIWI-family proteins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3458–3471.
Published: 15 September 2014
...Eva-Maria Weick; Eric A. Miska Distinguishing self from non-self plays a crucial role in safeguarding the germlines of metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi-interacting RNAs (piRNAs) have been shown to repress transposable elements in the germline...
Journal Articles
Journal: Development
Development (2014) 141 (13): 2592–2601.
Published: 01 July 2014
... restricted to the S phase of eukaryotic cells, is extended during the cell cycle of neoblasts. The planarian PIWI homologs SMEDWI-1 and SMEDWI-3 are required for proper localization of germinal histone H4 ( gH4 ) mRNA to chromatoid bodies. The association between histone mRNA and chromatoid body components...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (6): 1083–1094.
Published: 15 March 2012
..., reduced animal size, reduced number of neoblasts, fewer chromatoid bodies and increased levels of transposon and repetitive-element transcripts. Our results suggest that PIWI family member SMEDWI-3 is one sDMA-containing chromatoid body protein for which methylation depends on PRMT5. Additionally, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 4039–4050.
Published: 15 September 2011
...Andrea L. Zamparini; Marie Y. Davis; Colin D. Malone; Eric Vieira; Jiri Zavadil; Ravi Sachidanandam; Gregory J. Hannon; Ruth Lehmann In Drosophila , Piwi proteins associate with Piwi-interacting RNAs (piRNAs) and protect the germline genome by silencing mobile genetic elements. This defense system...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 237–243.
Published: 15 January 2011
... and piwi . In vivo lineage mapping of the cells awaits genetic manipulation of the lineage, but previous research has demonstrated that the germline is not specified at the fourth division because animals are fertile even when micromeres, the parent blastomeres of small micromeres, are deleted. Here, we...
Journal Articles
Journal: Development
Development (2010) 137 (24): 4113–4126.
Published: 15 December 2010
... other taxa segregate their germline after embryogenesis from multipotent progenitor cells. An overlapping set of genes, including vasa, nanos and piwi , operate in both multipotent precursors and in the germline. As we propose here, this conservation implies the existence of an underlying germline...
Journal Articles
Journal: Development
Development (2004) 131 (4): 839–849.
Published: 15 February 2004
...Satomi Kuramochi-Miyagawa; Tohru Kimura; Takashi W. Ijiri; Taku Isobe; Noriko Asada; Yukiko Fujita; Masahito Ikawa; Naomi Iwai; Masaru Okabe; Wei Deng; Haifan Lin; Yoichi Matsuda; Toru Nakano The piwi family genes, which are defined by conserved PAZ and Piwi domains, play important roles in stem...