... of homeostasis. The fenestral protein Plvap regulates the rate of plasma protein entry from the general circulation into the brain parenchyma. Fenestrae PV-1 PV1 Hypothalamus Pituitary Neurohypophysis Neuroendocrine Vascular permeability Blood-brain barrier Zebrafish Homeostasis...

... as they are clustered at the midline, resembling other midline structures important for maintaining the bilateral organization of the neural tube. Adhesion Cell movement Midline Pituitary Chick RNA-seq Sp8 Placodes are discrete thickenings of the cranial ectoderm localized in the proximity...

... of pituitary cell types. Here, we have used a genetic approach to demonstrate that activation of the SHH pathway is necessary to induce LHX3 + /LHX4 + RP identity in mouse embryos. First, we show that conditional deletion of Shh in the anterior hypothalamus results in a fully penetrant phenotype characterised...

...Sam Goldsmith; Robin Lovell-Badge; Karine Rizzoti Sox2 mutations are associated with pituitary hormone deficiencies and the protein is required for pituitary progenitor proliferation, but its function has not been well characterized in this context. SOX2 is known to activate expression of Six6...

... patterning. Our phenotypic analysis suggests that Boc is required as a positive regulator of Hh signaling in the spinal cord, hypothalamus, pituitary, somites and upper jaw, but that Boc might negatively regulate Hh signals in the lower jaw. This study reveals a role for Boc in ventral CNS cells that receive...

... a transient phase of cell death, which affects most, but not all adenohypophyseal cells. Surviving cells form a smaller pituitary rudiment,lack expression of specific adenohypophyseal marker genes ( pit1,neurod ), while expressing others ( lim3, pitx3 ), and display an ultrastructure reminiscent of precursor...

... ) * These authors contributed equally to this work 9 11 2005 © 2006. 2006 Retinoids Forebrain development Eye development Neural crest Telencephalon Diencephalon Optic vesicle Pituitary Sonic hedgehog FGF Mouse Aldh1a2 The embryonic forebrain...

...Wiebke Herzog; Carmen Sonntag; Sophia von der Hardt; Henry H. Roehl; Zoltan M. Varga; Matthias Hammerschmidt The pituitary gland consists of two major parts: the neurohypophysis, which is of neural origin; and the adenohypophysis, which is of non-neural ectodermal origin. Development...

... of vertebrate species. Its role in pituitary development has been documented through loss-of-function studies in the mouse. A homozygous missense point mutation resulting in a single amino acid substitution, Arg160Cys (R160C), is associated with a heritable form of the human condition of septo-optic dysplasia...

... a zebrafish ortholog of Smoothened that transduces Hedgehog signals. Zebrafish smoothened is expressed maternally and zygotically and supports specification of motoneurons, pituitary cells and ventral forebrain. We propose that smoothened is required for induction of lateral floor plate and a subpopulation...

.../0012-1606(87)90118-7 Eagleson , G. W. , Jenks , B. L. and van Overbeeke , A. P. ( 1986 ). The pituitary adrenocorticotropes originates from neural ridge tissue in Xenopus laevis . J. Embryol. Exp. Morph . 95 , 1 – 4 . Inoue , T. , Nakamura , S. and Osumi...

...Mathias Treier; Shawn O’Connell; Anatoli Gleiberman; Jenny Price; Daniel P. Szeto; Rob Burgess; Pao-Tien Chuang; Andrew P. McMahon; Michael G. Rosenfeld ABSTRACT Pituitary gland development serves as an excellent model system in which to study the emergence of distinct cell types from a common...

... in Hatschek’s left diverticulum as it forms the preoral ciliated pit, part of which gives rise to the homolog of the vertebrate anterior pituitary. A zone of expression in the anterior neural plate of early embryos is carried into the cerebral vesicle (a probable diencephalic homolog) during neurulation...

... addressed this issue in the embryonic anterior pituitary, an organ in which distinct hormone cell types are generated in a precise temporal and spatial order from an apparently homogenous ectodermal primordium. We provide evidence that in this tissue the coordinate control of progenitor cell identity...

... gene targeting forebrain patterning midbrain patterning hypothalamus pituitary growth regulation oxytocin lactation mammillary bodies Over the past few years there has been much progress in our understanding of the genetic regulation of the early patterning, growth and differentiation...

... of differentiation in a given cell lineage, we demonstrate that targeted oncogenesis can produce cell lines representing sequential stages of development, in essence allowing both spatial and temporal immortalization. Our strategy was based on our production of a committed but immature pituitary gonadotrope cell...

... in the prospective prosencephalic region of the neural plate ectoderm. Ultimately, transcripts become restricted to Rathke’s pouch, the primordium of the pituitary, which is known to be derived from the most anterior ectoderm of the early embryo. Down regulation of Rpx in the pouch coincides with the differentiation...

...Sheng-Cai Lin; Sen Li; Daniel W. Drolet; Michael G. Rosenfeld ABSTRACT The anterior pituitary provides a model to study the molecular mechanisms responsible for emergence of distinct cell types within an organ. Dwarf mice (Snell) that express a mutant form of the tissue-specific POU-domain...

...Kosuke Kawamura; Sakae Kikuyama To identify the origin of the primordial pituitary cells in early stages of amphibian embryos before the formation of Rathke’s pouch or its equivalent, transplantation experiments were carried out on Bufo . Wild-type embryos at the open neurula stage were employed...

... of anterior pituitary. * Corresponding author 07 12 1990 © 1991 by Company of Biologists 1991 engrailed Xenopus mandibular arch optic tectum pituitary The engrailed gene defines a subset of homeobox genes that have been highly conserved during evolution between...