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María José Andreu, Esther González-Pérez, Leiore Ajuria, Núria Samper, Sergio González-Crespo, Sonsoles Campuzano, Gerardo Jiménez
Development (2012) 139 (6): 1110–1114.
Published: 15 March 2012
... cells. A critical event regulated by EGFR signaling is the repression of the sulfotransferase-encoding gene pipe in dorsal follicle cells, but how this occurs remains unclear. Here we show that Mirror (Mirr), a homeodomain transcription factor induced by EGFR signaling in DA follicle cells, directly...
Includes: Supplementary data
Development (2007) 134 (8): 1465–1469.
Published: 15 April 2007
... is determined by the expression of the pipe gene in a subpopulation of ventral follicle cells in the developing egg chamber. The Pipe protein exhibits homology to vertebrate glycosaminoglycan sulfotransferases. In a previous study, we demonstrated that embryonic DV polarity depends upon the sulfotransferase...
Development (2005) 132 (17): 3813–3822.
Published: 01 September 2005
...Xianjun Zhu; Jonaki Sen; Leslie Stevens; Jason S. Goltz; David Stein The Drosophila pipe gene encodes ten related proteins that exhibit amino acid sequence similarity to vertebrate heparan sulfate 2-O-sulfotransferase. One of the Pipe isoforms, which is expressed in the ventral follicular...
Development (2002) 129 (12): 2965–2975.
Published: 15 June 2002
...Francesca Peri; Martin Technau; Siegfried Roth The restriction of Pipe, a potential glycosaminoglycan-modifying enzyme, to ventral follicle cells of the egg chamber is essential for dorsoventral axis formation in the Drosophila embryo. pipe repression depends on the TGFα-like ligand Gurken, which...
Development (2002) 129 (9): 2209–2222.
Published: 01 May 2002
... patterns the somatic follicular epithelium, establishing the dorsoventral asymmetry of eggshell and embryo. Analysis of follicle cell clones homozygous for a null allele of Ras demonstrates that Ras is required cell-autonomously to repress pipe transcription, the critical first step in embryonic...
Development (2001) 128 (22): 4553–4562.
Published: 15 November 2001
... ligand, Gurken. As a consequence, pipe is transcribed in a broad ventral domain to initiate the Toll signaling pathway in the embryo, resulting in a gradient of Dorsal nuclear translocation. We show that expression of pipe RNA requires the action of fettucine ( fet ) in ovarian follicle cells. Loss...
Development (2001) 128 (12): 2309–2319.
Published: 15 June 2001
... Dorsal peaks becomes deeper in older embryos ( Fig. 4 ). This observation suggests that signaling takes place over a period of time, and explains how an initial asymmetry, in the form of the broad stripe of pipe, might be gradually refined into a gradient of positional information. We present...