... mouse retina, the Ikaros zinc-finger transcription factor Ikzf1 regulates production of early-born cell types, except cone photoreceptors. In this study we show that, during early stages of retinal development, another Ikaros family protein, Ikzf4, functions redundantly with Ikzf1 to regulate cone...

...Awais Javed; Pierre Mattar; Suying Lu; Kamil Kruczek; Magdalena Kloc; Anai Gonzalez-Cordero; Rod Bremner; Robin R. Ali; Michel Cayouette ABSTRACT Multipotent retinal progenitor cells (RPCs) generate various cell types in a precise chronological order, but how exactly cone photoreceptor production...

...Noah B. Goodson; Michael A. Kaufman; Ko U. Park; Joseph A. Brzezinski, IV ABSTRACT The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers. PRDM1...

.... Human pluripotent stem cells Retina Cell culture Photoreceptors Differentiation Organoids The capacity to generate bona fide fetal-stage neural retinal cell types and tissues from human embryonic and induced pluripotent stem cells (hESCs and hiPSCs; collectively, hPSCs) has spurred...

... transcription factor Bsx controls zebrafish pineal gland development, laterality of the epithalamus and melatonin production. Bsx Brain-specific homeobox transcription factor Pineal gland Parapineal organ Habenula Epithalamus Photoreceptors Brain asymmetry Melatonin Development...

..., by modulating the canonical Notch pathway. Together, our results reveal a role for miR-124 in regulating the regeneration of a functional brain and visual system. Planarian Schmidtea mediterranea miR-124 Brain regeneration Photoreceptors Notch miRNA Fig. 2. Biophysical characterization...

... their essential role in photoreceptor differentiation. Furthermore, this circadian regulation was maintained in adult retina. Thus, once mature photoreceptors are formed, multiple retinal transcription factors fall under circadian clock control, at which point they appear to play a new and important role...

... in the expression profile of multiple basic helix-loop-helix transcription factors, consequently prompting premature cell-cycle exit and neuronal specification. Surprisingly, however, Notch1 inactivation led to a striking change in retinal cell composition, with cone-photoreceptor precursors expanding...

... regulatory sequences of the Xrx1A gene. We found that the expression ofΔFGFR4a in retinal progenitor cells results in abnormal retinal development. The retinas of transgenic animals expressing ΔFGFR4a show disorganized cell layering and specifically lack photoreceptor cells. These experiments show...

...C.-M. Amy Chen; Constance L. Cepko The paired type homeodomain gene, Rax , was previously identified as a key molecule in early eye formation in mice and humans. We report the expression patterns of two Rax family members from chicken, Rax and RaxL , and on the function of RaxL in photoreceptor...

...Todd C. Mockler; Hongwei Guo; Hongyun Yang; Hien Duong; Chentao Lin ABSTRACT The Arabidopsis photoreceptors cry1, cry2 and phyB are known to play roles in the regulation of flowering time, for which the molecular mechanisms remain unclear. We have previously hypothesized that phyB mediates a red...

...Mehmet E. Dokucu; S. Lawrence Zipursky; Ross L. Cagan ABSTRACT In the developing Drosophila retina, the proneural gene for photoreceptor neurons is atonal , a basic helix-loop-helix transcription factor. Using atonal as a marker for proneural maturation, we examine the stepwise resolution...

...S. Sanyal; R. K. Hawkins; H. G. Jansen; G. H. Zeilmaker ABSTRACT In the retina of chimaeric mice of rd and wild-type genotypic combination, selective loss of rd/rd photoreceptor cells, after initial development, leads to a mosaic retina with variable amounts of normal photoreceptor cells present...

... to elucidate the temporal and spatial aspects of the genesis of the cone mosaic in the developing retina, we generated a monoclonal antibody that specifically binds to the double cone photoreceptor of the adult. We first saw staining in the developing retina with this antibody, FRet 43, at 48 hours...