.... The importance of this complex interplay becomes evident after injury or in diseases in which aspects of axo-glial interaction are perturbed. This Review focuses on the specific interdependence of axons and Schwann cells in peripheral nerve development that enables axonal outgrowth, Schwann cell lineage...

.... These human Schwann cells promise to be a useful tool for cell-based therapies, disease modelling and drug discovery. Schwann cells are glia that support axons of peripheral nerves and are direct descendants of the embryonic neural crest. Peripheral nerves are damaged in various conditions, including through...

...Liang Wang; Alessandro Mongera; Dario Bonanomi; Lukas Cyganek; Samuel L. Pfaff; Christiane Nüsslein-Volhard; Till Marquardt In gnathostome vertebrates, including fish, birds and mammals, peripheral nerves link nervous system, body and immediate environment by integrating efferent pathways...

... to secondary hypogonadism. In addition, Ebf2 -/- peripheral nerves feature defective axon sorting,hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity. Ebf2 -null mice reveal a novel genetic cause of hypogonadotropic hypogonadism...

.... * Author for correspondence 15 09 1995 © 1995 by Company of Biologists 1995 Wallerian degeneration peripheral nerve axotomy nerve growth factor receptor myelin Schwann cell rat Myelin is a multi-lamellar structure that surrounds axons and increases axonal conduction...

... for correspondence * Present address: Department of Microbiology and Molecular Genetics, Harvard Medical School and Dana-Farber Cancer Institute, 44 Binney Street, Boston MA 02115, USA 21 02 1994 © 1994 by Company of Biologists 1994 neural crest migration peripheral nerve Schwann cell...

...M. Laura Feltri; Steven S. Scherer; Raffaello Nemni; John Kamholz; Helen Vogelbacker; Marion Oronzi Scott; Nicola Canal; Vito Quaranta; Lawrence Wrabetz ABSTRACT In developing and regenerating peripheral nerve, Schwann cells interact with axons and extracellular matrix in order to ensheath...

... of integrin heterodimers. In the present study, we have examined the expression and regulation of fibronectin and its integrin receptor, α 5 β 1 , in developing and regenerating chick peripheral nerve. We show that fibronectin and α 5 β 1 α 5 β 1 are expressed at comparatively high levels in developing nerve...

...Bernhard Wehrle-Haller; Manuel Koch; Stefan Baumgartner; Jürg Spring; Matthias Chiquet ABSTRACT The extracellular matrix protein, tenascin, appears in a restricted pattern during organ morphogenesis. Tenascin accumulates along developing peripheral nerves as they leave the spinal cord and enter...

...Bernhard Wehrle; Matthias Chiquet ABSTRACT The extracellular matrix protein, tenascin, appears in a restricted pattern during organ morphogenesis. Here we studied the expression of tenascin along developing peripheral nerves in chick embryos and tested its activity as a substrate for cultured...

... established developmental changes that occur in their surface lipids. © 1990 by Company of Biologists 1990 Schwann cells development myelination peripheral nerve GFAP NGF-receptor Some of the most important insights into Schwann cell development in recent years have come from studies...