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Keywords: pax8
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Journal Articles
Journal: Development
Development (2012) 139 (15): 2740–2750.
Published: 1 August 2012
... and Pax8 modulate commitment and behavior in cells that eventually contribute to the otic vesicle and epibranchial placodes. Initially, a subset of epibranchial placode precursors lie lateral to otic precursors within a single Pax2a/8-positive domain; these cells subsequently move to segregate...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3177–3190.
Published: 1 September 2007
...-catenin/TCF/Lef-dependent transcription coinciding with epithelial differentiation. We show in cultured explants that isolated activation ofβ-catenin signaling in epithelial progenitors induces, in a TCF/Lef-dependent manner, a subset of the transcripts associated with epithelialization, including Pax8...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 53–61.
Published: 1 January 2006
... path to reach the hindlimb level where it induces metanephros(adult kidney) formation, while the remaining duct gives rise to the male genital tract (epidydimis, vas deferens). The transcription factors Pax2 and Pax8 are essential for the initiation of pro- and mesonephros development. In a cDNA...
Journal Articles
Journal: Development
Development (2004) 131 (20): 5091–5102.
Published: 15 October 2004
... highly related paired box transcription factors Pax2a and Pax8 in the developing placode. We show that compromising the functions of both Pax2a and Pax8 together blocks zebrafish ear development, leaving only a few residual otic cells. This suggests that Pax2a and Pax8 are the main effectors downstream...
Journal Articles
Journal: Development
Development (2004) 131 (8): 1755–1763.
Published: 15 April 2004
... analysis of Sox9 during development of Xenopus inner ear. Sox9 otic expression is initiated shortly after gastrulation in the sensory layer of the ectoderm, in a bilateral patch of cells immediately adjacent to the cranial neural crest. In the otic placode, Sox9 colocalizes with Pax8 one of the earliest...
Journal Articles
Journal: Development
Development (2004) 131 (4): 923–931.
Published: 15 February 2004
... whether the observed ear defects were caused by faulty otic induction, we examined the expression of the preotic marker, pax8. Preotic expression of pax8 begins by 90% epiboly (9 hpf) in wild-type embryos( Pfeffer et al., 1998 ; Phillips et al., 2001 ), but was still not evident at tailbud stage (10...
Journal Articles
Journal: Development
Development (2003) 130 (11): 2543–2554.
Published: 1 June 2003
... regulator family, as the gene mutated in foo/foo embryos. foo is expressed in otic placode precursor cells, and foo/foo embryos lack placodal pax8 expression and have disorganized otic expression of pax2.1 and dlx3 . Third stream neural crest cell migration, detected by dlx2 and krox20 expression...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3751–3760.
Published: 1 August 2002
...-follicular group of cells. We show that pax2.1 and pax8, members of the zebrafish pax2/5/8 paralogue group, are expressed in the thyroid primordium. Whereas in mice, only Pax8 has a function during thyroid development, analysis of the zebrafish pax2.1 mutant no isthmus ( noi –/– ) demonstrates that pax2.1...