...Judith A. Blake; Melanie R. Ziman Pax genes encode a family of transcription factors that orchestrate complex processes of lineage determination in the developing embryo. Their key role is to specify and maintain progenitor cells through use of complex molecular mechanisms such as alternate RNA...

... for the formation of the VEG. Proteins encoded by the Pax gene family play a crucial role in animal development (for a review, see Chi and Epstein, 2002). Pax proteins contain up to three highly conserved protein domains: an N-terminal paired domain (PD) and a C-terminal homeodomain(HD), both of which...

... mutants Pax genes Scapula Skeletogenesis Tbx15 Although insight into the essentials of limb patterning has been rapidly increasing in recent years (Niswander,2003), the development of the shoulder and pelvic girdle has remained more elusive. The much-studied signaling centers...

... is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells. Development 124 , 761 -771. Jang, C. C., Chao, J. L., Jones, N., Yao, L. C., Bessarab, D. A., Kuo, Y. M., Jun, S., Desplan, C., Beckendorf, S. K. and Sun, Y. H. (2003). Two Pax genes...

...Lei Xue; Markus Noll The Drosophila Pax gene paired encodes a transcription factor that is required for the activation of segment-polarity genes and proper segmentation of the larval cuticle, postembryonic viability and male fertility. We show that paired executes a dual role in the development...

..., 1300 Morris Park Avenue, Bronx, NY 10461, USA § Author for correspondence (e-mail: [email protected]) 19 04 1999 05 03 1999 © 1999 by Company of Biologists 1999 Drosophila melanogaster Neurogenesis Sensory organ development shavevn (sv) Pax genes...

... 1999 © 1999 by Company of Biologists 1999 Neurogenesis Forebrain Optic stalk fgf8 pax genes acerebellar noisthmus Zebrafish Danio rerio During early vertebrate development, the nervous system becomes subdivided into discrete regions along its anterior- posterior...

... Pax genes no isthmus Zebrafish Danio rerio In vertebrate embryos, the fate of progenitor cells in the neural tube is determined by their position with respect to cellular sources of inducing signals (Lumsden and Krumlauf, 1996). Transplantation experiments in chicken suggest...

... or dispensable for others. * Author for correspondence (e-mail: [email protected]) 03 06 1998 02 04 1998 © 1998 by Company of Biologists 1998 Neurogenesis Regionalization Fgf8 acerebellar Pax genes Midbrain Hindbrain Organizer Zebrafish Somitogenesis...

[email protected]) † Current address: Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030-3498, USA 06 07 1997 © 1997 by Company of Biologists 1997 Caenorhabditis elegans PAX genes paired domain cell lineage pattern formation An important question...

... 1996 by Company of Biologists 1996 neurogenesis neural development regionalization pax genes isthmus rhombencephali midbrain hindbrain zebrafish Danio rerio no isthmus acerebellar One of the hallmarks of the central nervous system (CNS) is the enormous number...

... genes BMP proteins somitic differentiation neural tube polarisation vertebral cartilage formation Pax genes In a previous study carried out on the avian embryo, we have shown that the vertebra is composed of two regions, the development of which obeys distinct regulatory mechanisms...

... RED domain is dispensable, consistent with crystallographic data that indicate that it does not bind to DNA (Xu et al., 1995) and in contrast to other Pax genes where this domain has been shown to function as an independent DNAbinding domain (Epstein et al., 1994). In addition, we show...

... by Company of Biologists 1996 cooperativity DNA binding homeodomain paired domain Pax genes The Pax proteins are a family of important developmental regulators that are characterized by an evolutionarily conserved DNA binding domain, the paired domain (PD; Bopp et al., 1986 ; Treisman...

...Patrick Tremblay; Fabienne Pituello; Peter Gruss ABSTRACT The Pax genes containing a complete paired-type homeobox are expressed in restricted dorsoventral domains of the undifferentiated neuroepithelium. Their expression respond to signals that pattern the neural tube and which emanate from...

... dorsal neural tube, surface ectoderm and dorsomedial somite regions in specifying epaxial musculature are discussed. * Author for correspondence at address 1 18 09 1995 © 1996 by Company of Biologists 1996 neural tube Pax genes myogenic factors somite hypaxial muscle...

...Martyn D. Goulding; Andrew Lumsden; Peter Gruss ABSTRACT Members of the paired box (Pax) gene family are expressed in discrete regions of the developing central nervous system, suggesting a role in neural patterning. In this study, we describe the isolation of the chicken homologues of Pax-3...