... to a differentiated scale precursor and its associated socket cell. Single-nucleus RNA sequencing using early pupal wings revealed differential gene expression patterns that mirror SOP development, suggesting a shared developmental program. Additionally, we recovered a newly associated gene, the transcription factor...

...Virginia L. Pimmett; James McGehee; Antonio Trullo; Maria Douaihy; Ovidiu Radulescu; Angelike Stathopoulos; Mounia Lagha Morphogen gradients convey essential spatial information during tissue patterning. While both concentration and timing of morphogen exposure are crucial, how cells interpret...

...Tim J. Yeung; David G. Wilkinson ABSTRACT In the vertebrate nervous system, neurogenesis generally precedes gliogenesis. The mechanisms driving the switch in cell type production and generation of the correct proportion of cell types remain unclear. Here, we show that Fgf20 signalling patterns...

... by The Company of Biologists Ltd 2024 Summary: This Spotlight looks at the history of the C. elegans homeobox field, discussing the prevalent role of homeodomain protein expression and function in C. elegans nervous system development. C. elegans Hox Homeobox Neural development Patterning...

...Lewis S. Mosby; Amy E. Bowen; Zena Hadjivasiliou ABSTRACT Much of the striking diversity of life on Earth has arisen from variations in the way that the same molecules and networks operate during development to shape and pattern tissues and organs into different morphologies. However, we still...

...Rodrigue Peraldi; Marie Kmita ABSTRACT Animal body plans are established during embryonic development by the Hox genes. This patterning process relies on the differential expression of Hox genes along the head-to-tail axis. Hox spatial collinearity refers to the relationship between...

... and kidney, and most glands, and is the net result of two tissue behaviors: branch point initiation and elongation. Each branched organ has a distinct architecture customized to its physiological function, but how patterning occurs in these ramified tubular structures is a fundamental problem of development...

... is established during kidney development. More specifically, how signals from the kidney influence vessel maturity and patterning remains poorly understood. Netrin 1 (Ntn1) is a secreted ligand that is crucial for vessel and neuronal guidance. Here, we demonstrate that Ntn1 is expressed by Foxd1 + stromal...

...-most NT. The OLIG2 domain is also subsequently lost, eventually producing a NT that is entirely positive for the dorsal marker PAX3. Thus, a terminal myelocystocele-like phenotype can arise after completion of NT closure with localised spinal mis-patterning caused by disruption of FGFR1 signalling...

... the Fgf8a gradient curve with expression profiles of its downstream targets determines the precise input-output relationship of Fgf8a-mediated patterning. Manipulation of the extracellular Fgf8a levels alters the signaling outcome, thus establishing Fgf8a as a bona fide morphogen during zebrafish...

... of head regeneration and patterning defects in amputated tail fragments. alx-3 is required for the expression of several early wound-induced genes, including the Wnt inhibitor notum , which is required to establish anterior polarity during regeneration. Together, these findings reveal a role for alx-3...

...Nicole A. Repina; Hunter J. Johnson; Xiaoping Bao; Joshua A. Zimmermann; David A. Joy; Shirley Z. Bi; Ravi S. Kane; David V. Schaffer ABSTRACT In embryonic stem cell (ESC) models for early development, spatially and temporally varying patterns of signaling and cell types emerge spontaneously...

...Hasan Asfour; Estelle Hirsinger; Raquel Rouco; Faouzi Zarrouki; Shinichiro Hayashi; Sandra Swist; Thomas Braun; Ketan Patel; Frédéric Relaix; Guillaume Andrey; Sigmar Stricker; Delphine Duprez; Amalia Stantzou; Helge Amthor ABSTRACT The mechanism of pattern formation during limb muscle development...

...Jan A. Adelmann; Roman Vetter; Dagmar Iber ABSTRACT Tissue patterning during embryonic development is remarkably precise. Here, we numerically determine the impact of the cell diameter, gradient length and the morphogen source on the variability of morphogen gradients. We show that the positional...

... and reproduction in any medium provided that the original work is properly attributed. Highlighted Article: Relative intercellular asymmetry is a crucial factor underlying the robustness of persistently directional collective cell rotations in vivo . Multicellular rotations Patterning...

... to alternating patterns (e.g. SOP selection, hair cell in the inner ear and neural stem cell maintenance), as well as processes where Notch activity is oscillatory (e.g. somitogenesis and neurogenesis in mammals). * Author for correspondence ( [email protected] ) Competing interests...

...-HPE). In this study, we have identified a previously unreported downstream mediator of retinoic acid (RA) signaling, CNKSR2 , which is expressed in the forebrain roof plate in the chick embryo. Knockdown of CNKSR2 affects invagination, cell proliferation and patterning of the roof plate, similar...

... paralogous group, the anterior boundary of expression for each Hox gene is fixed and vertebral axial fate and morphology are irreversibly established (reviewed by Mallo et al., 2010 ; Wellik, 2007 ). Each Hox paralog group exhibits a high level of functional redundancy in patterning the axial vertebrae...

... for simulating human systems . Proc. Natl. Acad. Sci. USA 99 , 7280 - 7287 . 10.1073/pnas.082080899 Brinkmann , F. , Mercker , M. , Richter , T. and Marciniak-Czochra , A. ( 2018 ). Post-turing tissue pattern formation: advent of mechanochemistry . PLoS Comput. Biol. 14...

... on the SHH/BMP4 signaling axis to regulate mesenchymal patterning and differentiation. Mouse embryos with conditional loss of Fgfr1 and Fgfr2 in the ureteric mesenchyme exhibited reduced mesenchymal proliferation and prematurely activated lamina propria formation at the expense of the smooth muscle cell...