... as paraxial mesoderm. By contrast, haemogenic potential is well established for extra-embryonic mesoderm and intra-embryonic lateral plate mesoderm, which do not express Pax3 . To date, it is not known whether the haematopoietic system also contains Pax3 lineage cells. Here, we show that the mouse foetal...

... is enhanced by TGFβ ( Pryce et al., 2009 ) and inhibited by BMP ( Bi et al., 2007 ; Schweitzer et al., 2001 ). The original KDR −/lo PDGFRα + paraxial mesoderm fraction contained cells that expressed SOX9 (‘PM’ in Fig. 2 C). However, when the KDR −/lo PDGFRα + cells were grown in culture, the level...

... Paraxial mesoderm Olig2 Pax7 Retinoic acid Somite The sonic hedgehog (Shh) protein plays fundamental roles in the development of the neural tube (NT) and somites ( Borycki et al., 1998 ; Briscoe, 2009 ; Cairns et al., 2008 ; Ericson et al., 1997a , b ; Gustafsson et al., 2002 ). Its...

.... Differentiation Disease modeling Fibrodysplasia ossificans progressiva Induced pluripotent stem cells Paraxial mesoderm Recapitulation of endogenous signaling environments is considered to be key for the induction of desired cell types from pluripotent stem cells (PSCs). Developmental biology studies...

... Body skeletal muscles derive from the paraxial mesoderm, which forms in the posterior region of the embryo. Using microarrays, we characterize novel mouse presomitic mesoderm (PSM) markers and show that, unlike the abrupt transcriptome reorganization of the PSM, neural tube differentiation...

... lateral plate differentiation is profoundly altered. During this period, global mRNA levels are unchanged in the PSM, with only a minor subset of genes dysregulated. Together, our data strongly suggest that the TAF10-containing canonical TFIID and SAGA complexes are dispensable for early paraxial mesoderm...

... of Biologists Ltd 2017 Summary: This Review discusses the mechanisms that underpin the formation of skeletal muscle during development and its recapitulation from pluripotent stem cells in vitro . Skeletal myogenesis Muscle differentiation Paraxial mesoderm Somite Dermomyotome Muscular...

... Paraxis: a regulator of paraxial mesoderm development and somite formation . Dev. Biol.   189 , 95 - 111 . 10.1006/dbio.1997.8663 Barrios , A. , Poole , R. J. , Durbin , L. , Brennan , C. , Holder , N. and Wilson , S. W. ( 2003 ). Eph/Ephrin signaling regulates...

...Robert J. Garriock; Ravindra B. Chalamalasetty; Mark W. Kennedy; Lauren C. Canizales; Mark Lewandoski; Terry P. Yamaguchi In the development of the vertebrate body plan, Wnt3a is thought to promote the formation of paraxial mesodermal progenitors (PMPs) of the trunk region while suppressing neural...

... 2014 © 2014. Published by The Company of Biologists Ltd 2014 bHLH transcription factor Paraxial mesoderm PSM Differentiation EMT Motility Wnt Embryonic stem cell Somite Mouse The process of vertebrate body formation provides an excellent opportunity to understand...

...Jiangang Zhao; Songhui Li; Suprita Trilok; Makoto Tanaka; Vanta Jokubaitis-Jameson; Bei Wang; Hitoshi Niwa; Naoki Nakayama Pluripotent embryonic stem cells (ESCs) generate rostral paraxial mesoderm-like progeny in 5-6 days of differentiation induced by Wnt3a and Noggin (Nog). We report...

... tail somites. Through its combined effects on gene expression and cell movement, Msgn1 (with Spt) plays a key role both in genesis of the paraxial mesoderm and in maintenance of the progenitor population from which it derives. * Authors for correspondence ( [email protected] ; [email protected]...

... patterning, in which Wnt3a from the paraxial mesoderm induces posterior cell fates via direct activation of a crucial transcription factor in the overlying neural plate. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial...

... plate mesoderm. † Author for correspondence (e-mail: [email protected] ) * Present address: Division of Vascular Surgery, University of Cologne,Cologne, Germany 17 3 2008 © 2008. 2008 Vascular smooth muscle cell Aorta Lateral plate mesoderm Paraxial mesoderm...

... are expressed in mitotically active muscle progenitors in the dermomyotome ( Relaix et al., 2004 ). As these cells differentiate into muscle they express myogenic regulatory factors (MRFs) such as MyoD, Myf5 and myogenin( Relaix, 2006 ). Myotome Anterior border cells Cell fate Paraxial mesoderm...

... in mesoderm development. Unlike Bmpr1a -null embryos, which fail to gastrulate, Bmpr-MORE embryos initiate gastrulation, but the recruitment of prospective paraxial mesoderm cells to the primitive streak is delayed. This delay causes a more proximal distribution of cells with paraxial mesoderm character...

... and amphibian embryos. Here, we analyze the molecular mechanisms of neural crest induction by the mesoderm in Xenopus embryos. Using a recombination assay, we show that prospective paraxial mesoderm induces a panel of neural crest markers ( Slug, FoxD3, Zic5 and Sox9 ),whereas the future axial mesoderm only...

... temporal activation of expression and the establishment of the correct anterior boundary in the paraxial mesoderm (somite 6/7). However, the Hoxb4 promoter is required to maintain this expression beyond 8.5 dpc. In addition, sequences within the 3′ untranslated region (region B)are necessary specifically...

... potential downstream components of Notch signaling are lacking in her1+7 -deficient embryos, somite boundaries form, but do so with a one and a half to two segment periodicity. ‡Author for correspondence (e-mail: [email protected] ) 9 5 2002 © 2002. 2002 Paraxial mesoderm...

... environment. Results from experiments in which posterior neural segments and/or paraxial mesoderm segments were placed at different axial levels suggest that signals setting Hoxd10 expression form a decreasing posterior-to-anterior gradient. Our experiments do not, however, implicate adjacent paraxial...