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Keywords: par-1
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Journal Articles
Journal: Development
Development (2018) 145 (14): dev166165.
Published: 30 July 2018
... in this process. Interestingly, visualization of InR -depleted BC clusters, using time-lapse imaging, revealed a delay in detachment of BC clusters from the surrounding anterior follicle cells and altered protrusion dynamics. Lastly, based on genetic interactions between InR , the polarity determinant, par-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev166165.
Published: 30 July 2018
... in this process. Interestingly, visualization of InR -depleted BC clusters, using time-lapse imaging, revealed a delay in detachment of BC clusters from the surrounding anterior follicle cells and altered protrusion dynamics. Lastly, based on genetic interactions between InR , the polarity determinant, par-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2984–2992.
Published: 1 August 2014
...Eurico Morais-de-Sá; Avik Mukherjee; Nick Lowe; Daniel St Johnston The Drosophila anterior-posterior axis is specified when the posterior follicle cells signal to polarise the oocyte, leading to the anterior/lateral localisation of the Par-6/aPKC complex and the posterior recruitment of Par-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5441–5450.
Published: 15 December 2011
... protein that is expressed in neuroectoderm adjacent to the NC territory, is required for NC formation. Wnt11-like signals might specify NC by altering the localization and activity of the serine/threonine polarity kinase PAR-1 (also known as microtubule-associated regulatory kinase or MARK), which itself...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (10): 1765–1773.
Published: 15 May 2010
... poles of the cell. Oocyte polarity has been proposed to depend on the same PAR proteins that generate AP polarity in C. elegans , with a complex of Bazooka (Baz; Par-3), Par-6 and aPKC marking the anterior and lateral cortex, and Par-1 defining the posterior. The function of the Baz complex in oocyte...
Journal Articles
Journal: Development
Development (2010) 137 (4): 661–670.
Published: 15 February 2010
... it does not affect embryonic polarity. Instead, we found that the PAR-4-mediated phosphorylation of polarity regulators such as PAR-1 and MEX-5 in the early embryo occurs in the absence of STRD-1. Thus, PAR-4 requires STRD-1 to phosphorylate AMPK to regulate cell growth/proliferation under reduced insulin...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3665–3675.
Published: 15 November 2008
... polarity proteins. Through mechanisms that are not understood, the kinases PAR-1 and PAR-4, and other PAR proteins cause the cytoplasmic zinc finger protein MEX-5 to accumulate asymmetrically in the anterior half of the one-cell embryo. We show that MEX-5 asymmetry requires neither vectorial transport...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 463–471.
Published: 1 February 2008
... to the oocyte posterior, thereby dividing the cortex into different domains along the AP axis. Active Lgl promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of the serine/threonine kinase Par-1, a key step for oocyte polarization. Our studies suggest that Lgl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2747–2756.
Published: 15 July 2006
... to MELK, a conserved member of the polarity-regulating PAR-1/Kin1/SAD-1 family of serine/threonine kinases. Although MELK has been implicated in regulating the cell cycle, our data suggest that PIG-1, like other PAR-1 family members, regulates cell polarity. To address whether pig-1 mutations perturb...
Journal Articles
Journal: Development
Development (2004) 131 (23): 5897–5907.
Published: 1 December 2004
...Veit Riechmann; Anne Ephrussi The Ser/Thr kinase Par-1 is required for cell polarisation in diverse organisms such as yeast, worms, flies and mammals. During Drosophila oogenesis, Par-1 is required for several polarisation events, including localisation of the anterior determinant bicoid...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (1997) 124 (19): 3815–3826.
Published: 1 October 1997
... par-1 par-2 par-3 par-4 skn-1 The generation of asymmetry before mitosis is a general mechanism for producing cells with different fates during growth and development (for a review, see Gonczy and Hyman, 1996 ). For example, sperm entry provides an extrinsic cue to polarize the 1...
Journal Articles