... remain unknown. Here, we show that the highly conserved basic helix-loop-helix (bHLH)transcription factor Hand is expressed in cardioblasts, pericardial nephrocytes and hematopoietic progenitors. The homeodomain protein Tinman and the GATA factors Pannier and Serpent directly activate Hand in these cell...

... pannier ( pnr ) controls Iroquois-Complex ( Iro-C ) genes to establish the dorsal eye fate whereas Lobe ( L ), which is involved in controlling a Notch ligand Serrate ( Ser ), is specifically required for ventral growth. However, fate of eye disc cells before the onset of dorsal expression of pnr and Iro...

... of Tinman, a mesoderm-specific homeobox transcription factor. We present evidence that the Gata transcription factor, Pannier, and its binding partner U-shaped, also a zinc-finger protein, cooperate in the process of heart development. Loss-of-function and germ layer-specific rescue experiments suggest...

...Corinna Wülbeck; Pat Simpson The Drosophila gene pannier ( pnr ) has recently been assigned to a new class of selector genes (Calleja, M., Herranz, H., Estella, C., Casal, J., Lawrence, P., Simpson, P. and Morata, G. (2000). Development 127, 3971-3980; (Mann, R. S. and Morata, G. (2000). Annu. Rev...

... future bristle. Expression relies on a series of discrete cis- regulatory elements present in the ac-sc gene complex that are the target of the transcriptional activators pannier ( pnr ) and the genes of the iroquois complex. Stereotyped bristle patterns are common among species of acalyptrate...

... activators such as Pannier. Other species of derived schizophoran Diptera have equally stereotyped, but different, bristle patterns. Divergence of bristle patterns could arise from changes in the expression pattern of proneural genes, resulting from evolution of the cis -regulatory sequences and/or altered...

... at the fringe expression boundary at the midline. The secreted protein Wingless activates the dorsal expression of the iroquois genes. We show here that pannier , which encodes a GATA family transcription factor expressed at the dorsal margin of the eye disc from embryonic stages on, acts upstream of wingless...

... specification. In Drosophila , the existence of a cardiogenic GATA factor has been implicated through the analysis of a cardial cell enhancer of the muscle differentiation gene D-mef2 . We show that the GATA gene pannier is expressed in the dorsal mesoderm and required for cardial cell formation while...

...María J. García-García; Philippe Ramain; Pat Simpson; Juan Modolell In Drosophila , the GATA family transcription factor Pannier and the Wnt secreted protein Wingless are known to be important for the patterning of the notum, a part of the dorsal mesothorax of the fly. Thus, both proteins...

...Philippe Ramain; Pascal Heitzler; Marc Haenlin; Pat Simpson ABSTRACT The gene pannier acts as a repressor of achaete and scute , two transcription factors expressed in discrete subsets of cells at the sites where neural precursors develop. Molecular analysis of mutant alleles revealed the presence...