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1-20 of 83
Keywords: pancreas
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Journal Articles
Journal:
Development
Development (2024) 151 (9): dev202191.
Published: 10 May 2024
... how gene expression oscillations encode temporal information during vertebrate embryonic development by discussing the gene expression oscillations occurring during somitogenesis, neurogenesis, myogenesis and pancreas development. These oscillations play important but varied physiological functions...
Journal Articles
Journal:
Development
Development (2024) 151 (2): dev202254.
Published: 24 January 2024
...Rikke Hoegsberg Agerskov; Pia Nyeng ABSTRACT The autonomic nervous system innervates the pancreas by sympathetic, parasympathetic and sensory branches during early organogenesis, starting with neural crest cell invasion and formation of an intrinsic neuronal network. Several studies have...
Journal Articles
Journal:
Development
Development (2022) 149 (20): dev201004.
Published: 31 October 2022
...Anne Grapin-Botton; Yung Hae Kim ABSTRACT Organoids have become one of the fastest progressing and applied models in biological and medical research, and various organoids have now been developed for most of the organs of the body. Here, we review the methods developed to generate pancreas...
Journal Articles
Uylissa A. Rodriguez, Shakti Dahiya, Michelle L. Raymond, Chenxi Gao, Christina P. Martins-Cargill, Jon D. Piganelli, George K. Gittes, Jing Hu, Farzad Esni
Journal:
Development
Development (2022) 149 (17): dev200761.
Published: 8 September 2022
... heavily on the spatiotemporal recruitment of the endothelial cells to the embryonic pancreas. Although it is known that VEGFA secreted by the epithelium recruits the endothelial cells to the specific domains within the developing pancreas, the mechanism that controls the timing of such recruitment...
Includes: Supplementary data
Journal Articles
Laura Glorieux, Aleksandra Sapala, David Willnow, Manon Moulis, Anna Salowka, Jean-Francois Darrigrand, Shlomit Edri, Anat Schonblum, Lina Sakhneny, Laura Schaumann, Harold F. Gómez, Christine Lang, Lisa Conrad, Fabien Guillemot, Shulamit Levenberg, Limor Landsman, Dagmar Iber, Christophe E. Pierreux, Francesca M. Spagnoli
Journal:
Development
Development (2022) 149 (3): dev199655.
Published: 4 February 2022
... imaging approaches, our current knowledge of the spatial organization of distinct cell types in the embryonic pancreatic tissue is still largely based on two-dimensional histological sections. Here, we present a light-sheet fluorescence microscopy approach to image the pancreas in three dimensions and map...
Includes: Supplementary data
Journal Articles
Sumeet Pal Singh, Prateek Chawla, Alisa Hnatiuk, Margrit Kamel, Luis Delgadillo Silva, Bastiaan Spanjaard, Sema Elif Eski, Sharan Janjuha, Pedro Olivares-Chauvet, Oezge Kayisoglu, Fabian Rost, Juliane Bläsche, Annekathrin Kränkel, Andreas Petzold, Thomas Kurth, Susanne Reinhardt, Jan Philipp Junker, Nikolay Ninov
Journal:
Development
Development (2022) 149 (2): dev199853.
Published: 28 January 2022
... pancreas. Our work provides an atlas of β-cell regeneration and indicates that the rapid formation of glucose-responsive hybrid cells contributes to the resolution of diabetes in zebrafish * Equal contribution as first authors ‡ Author for correspondence ( [email protected]...
Includes: Supplementary data
Journal Articles
Anna B. Osipovich, Karrie D. Dudek, Emily Greenfest-Allen, Jean-Philippe Cartailler, Elisabetta Manduchi, Leah Potter Case, Eunyoung Choi, Austin G. Chapman, Hannah W. Clayton, Guoqiang Gu, Christian J. Stoeckert, Jr, Mark A. Magnuson
Journal:
Development
Development (2021) 148 (6): dev196964.
Published: 21 March 2021
... that the clustered protocadherin genes are differentially expressed during pancreas development. Pcdhγ genes are preferentially expressed in pancreatic endoderm, Pcdhβ genes in nascent islets, and Pcdhα genes in mature β-cells. Second, after extracting sub-networks of transcriptional regulators for each...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2020) 147 (7): dev179051.
Published: 12 April 2020
... states, cellular heterogeneity and molecular trajectories of β-cell generation and regeneration. Pancreas β Cell Single-cell RNA-seq Cell lineage differentiation Trans-differentiation Cellular plasticity National Key Research and Development Program of China 2019YFA0801500...
Journal Articles
Seokho Kim, Robert L. Whitener, Heshan Peiris, Xueying Gu, Charles A. Chang, Jonathan Y. Lam, Joan Camunas-Soler, Insung Park, Romina J. Bevacqua, Krissie Tellez, Stephen R. Quake, Jonathan R. T. Lakey, Rita Bottino, Pablo J. Ross, Seung K. Kim
Journal:
Development
Development (2020) 147 (6): dev186213.
Published: 30 March 2020
... pancreatic genetics, development and islet function could limit progress in developing interventions for human diseases such as diabetes mellitus. Similarities of pancreas morphology and function suggest that porcine and human pancreas developmental biology may have useful homologies. However, little...
Includes: Supplementary data
Journal Articles
Sri Teja Mullapudi, Giulia L. M. Boezio, Andrea Rossi, Michele Marass, Ryota L. Matsuoka, Hiroki Matsuda, Christian S. M. Helker, Yu Hsuan Carol Yang, Didier Y. R. Stainier
Journal:
Development
Development (2019) 146 (21): dev173674.
Published: 4 November 2019
... in tissue architecture and function. Pancreas Vasculature Beta cells VEGF Zebrafish Specialized to sense and rapidly respond to circulating metabolites, pancreatic islets are crucial in regulating glucose homeostasis. Attesting to their importance, these endocrine cell clusters are densely...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Cyrille Ramond, Belin Selcen Beydag-Tasöz, Ajuna Azad, Martijn van de Bunt, Maja Borup Kjær Petersen, Nicola L. Beer, Nicolas Glaser, Claire Berthault, Anna L. Gloyn, Mattias Hansson, Mark I. McCarthy, Christian Honoré, Anne Grapin-Botton, Raphael Scharfmann
Journal:
Development
Development (2018) 145 (16): dev165480.
Published: 15 August 2018
... of cells present in the human fetal pancreas and their lineage relationships, we developed strategies to isolate pancreatic progenitors, endocrine progenitors and endocrine cells. Transcriptome analysis of the individual populations revealed a large degree of conservation among vertebrates in the drivers...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2018) 145 (12): dev161372.
Published: 8 June 2018
...Maja B. Gere-Becker; Claudia Pommerenke; Thomas Lingner; Tomas Pieler ABSTRACT Retinoic acid (RA) is required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA signalling in this context remains to be defined. By RNA sequencing...
Includes: Supplementary data
Journal Articles
Julia Freudenblum, José A. Iglesias, Martin Hermann, Tanja Walsen, Armin Wilfinger, Dirk Meyer, Robin A. Kimmel
Journal:
Development
Development (2018) 145 (3): dev158477.
Published: 8 February 2018
... of imaging internal organs with cellular resolution. Within transparent zebrafish larvae, the developing pancreas is relatively superficial and thus amenable to live imaging approaches. We performed in vivo time-lapse and longitudinal imaging studies to follow islet development, visualizing both naturally...
Includes: Supplementary data
Journal Articles
Katie L. Sinagoga, William J. Stone, Jacqueline V. Schiesser, Jamie I. Schweitzer, Leesa Sampson, Yi Zheng, James M. Wells
Journal:
Development
Development (2017) 144 (13): 2402–2414.
Published: 1 July 2017
...Katie L. Sinagoga; William J. Stone; Jacqueline V. Schiesser; Jamie I. Schweitzer; Leesa Sampson; Yi Zheng; James M. Wells While much is known about the molecular pathways that regulate embryonic development and adult homeostasis of the endocrine pancreas, little is known about what regulates early...
Includes: Supplementary data
Journal Articles
In collection:
Chromatin and epigenetics
Journal:
Development
Development (2016) 143 (19): 3573–3581.
Published: 1 October 2016
... at pancreatic regulatory regions, possibly through interaction with the endodermal TF Foxa2. Taken together, our data suggest that Setd7 acts as a central component of the TF/chromatin complex initiating the pancreatic program. To start investigating the function of Setd7 in early pancreas development...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2016) 143 (5): 780–786.
Published: 1 March 2016
...Shouhong Xuan; Lori Sussel GATA4 and GATA6 are zinc finger transcription factors that have important functions in several mesodermal and endodermal organs, including heart, liver and pancreas. In humans, heterozygous mutations of either factor are associated with pancreatic agenesis; however...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2015) 142 (18): 3126–3137.
Published: 15 September 2015
...Rachel E. Jennings; Andrew A. Berry; James P. Strutt; David T. Gerrard; Neil A. Hanley A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here...
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2015) 142 (8): 1407–1417.
Published: 15 April 2015
... initially exhibit some characteristics of α cells but subsequently matures into a β cell. Intriguingly, the presence of insulin :mCherry and glucagon :GFP dual-positive cells in the non-ablated larval and adult zebrafish pancreas suggests that this process might be active in the homeostasis of the islet...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Laurence A. Lemaire, Joan Goulley, Yung Hae Kim, Solenne Carat, Patrick Jacquemin, Jacques Rougemont, Daniel B. Constam, Anne Grapin-Botton
Journal:
Development
Development (2015) 142 (5): 858–870.
Published: 1 March 2015
... cell over-proliferation and cyst formation. Transcriptome comparison between WT and Bicc1 KO pancreata, before the phenotype onset, reveals that PKD2 functions downstream of BICC1 in preventing cyst formation in the pancreas. Moreover, the analysis highlights immune cell infiltration and stromal...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2015) 142 (5): 871–882.
Published: 1 March 2015
...Matias G. De Vas; Janel L. Kopp; Claire Heliot; Maike Sander; Silvia Cereghini; Cécile Haumaitre Heterozygous mutations in the human HNF1B gene are associated with maturity-onset diabetes of the young type 5 (MODY5) and pancreas hypoplasia. In mouse, Hnf1b heterozygous mutants do not exhibit any...
Includes: Supplementary data
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