... in palatogenesis through the control of ciliary homeostasis, which establishes a new mechanism for Wnt-regulated craniofacial morphogenesis. * Author for correspondence ( [email protected] ) Handling Editor: Liz Robertson Competing interests The authors declare no competing or financial interests...

...Kendall J. Lough; Danielle C. Spitzer; Abby J. Bergman; Jessica J. Wu; Kevin M. Byrd; Scott E. Williams; Sally Dunwoodie; John Wallingford ABSTRACT Cleft palate (CP), one of the most common congenital conditions, arises from failures in secondary palatogenesis during embryonic development. Several...

... Wnt signaling and led to the growth and fusion of palatal shelves, as marked by an increase in cell proliferation and osteogenesis in utero , while other organ defects were not corrected. This work underscores the importance of Pax9-dependent Wnt signaling in palatogenesis and suggests...

...Jeffrey O. Bush; Rulang Jiang Mammalian palatogenesis is a highly regulated morphogenetic process during which the embryonic primary and secondary palatal shelves develop as outgrowths from the medial nasal and maxillary prominences, respectively, remodel and fuse to form the intact roof...

..., MN). The expression of Wnt5a and its receptors Fzd4 and Ror2 suggests a role for these genes in palatogenesis. The fact that Ror2 knockout mice exhibit a cleft palate phenotype( Schwabe et al., 2004 ) and that individuals with non-syndromic cleft lip and palate have been linked...

... a crucial, cell-autonomous role in regulating the fate of CNC cells during palatogenesis. During skull development, disruption of TGFβ signaling in the CNC severely impairs cell proliferation in the dura mater, consequently resulting in calvaria agenesis. We provide in vivo evidence that TGFβ signaling...

... be addressed © 1990 by Company of Biologists 1990 TGF beta in situ hybridisation mouse embryo palatogenesis The murine secondary palate arises from the bilateral maxillary processes of the head. These structures are composed of migratory neural crest cells associated...