...Teng Teng; Camilla S. Teng; Vesa Kaartinen; Jeffrey O. Bush ABSTRACT Tissue fusion frequently requires the removal of an epithelium that intervenes distinct primordia to form one continuous structure. In the mammalian secondary palate, a midline epithelial seam (MES) forms between two palatal...

... effectors is regulated to mediate gene expression changes have not been defined. We find that the RNA-binding protein Srsf3 is phosphorylated at Akt consensus sites downstream of PI3K-mediated PDGFRα signaling in mouse palatal mesenchyme cells, leading to its nuclear translocation. We further demonstrate...

... and are often hard to relate to real interactions measured experimentally. Addressing these issues, we investigated the periodic striped patterning of the rugae (transverse ridges) in the mammalian oral palate, focusing on multiple previously implicated pathways: FGF, Hh, Wnt and BMP. For each, we...

... between Wnt-secreting and receiving cells during convergent-extension remain elusive. We investigated the role and genetic interactions of Wnt ligands and their trafficking factors Wls, Gpc4 and Frzb in the context of palate morphogenesis in zebrafish. We describe that the chaperon Wls and its ligands...

... mechanisms, specifically cell shape change, orientated cell division and cell rearrangement, are rarely considered or quantified, particularly in mammalian systems. Their quantification, together with proliferation, provides a rigorous framework for the analysis of elongation. The mammalian palatal...

...Max Dougherty; George Kamel; Michael Grimaldi; Lisa Gfrerer; Valeriy Shubinets; Renee Ethier; Graham Hickey; Robert A. Cornell; Eric C. Liao Development of the palate in vertebrates involves cranial neural crest migration, convergence of facial prominences and extension of the cartilaginous...

... interests. © 2012. Heart Neural tube Palate Tissue fusion During embryonic development, there are many instances when two opposing tissues come into contact and fuse together to form one continuous structure. This type of tissue fusion occurs during the formation of many organs...

...Jun Han; Julie Mayo; Xun Xu; Jingyuan Li; Pablo Bringas, Jr; Richard L. Maas; John L. R. Rubenstein; Yang Chai Cleft palate represents one of the most common congenital birth defects in human. During embryonic development, palatal shelves display oronasal (O-N) and anteroposterior polarity before...

...Wei Liu; Xiaoxia Sun; Alen Braut; Yuji Mishina; Richard R. Behringer; Mina Mina; James F. Martin Previous work suggested that cleft lip with or without cleft palate (CL/P)is genetically distinct from isolated cleft secondary palate (CP). Mutations in the Bmp target gene Msx1 in families with both...

...Mark W. J. Ferguson ABSTRACT In all vertebrates, the secondary palate arises as bilateral outgrowths from the maxillary processes. In birds and most reptiles, these palatal shelves grow initially horizontally, but do not fuse with each other resulting in physiological cleft palate. In crocodilians...

...Robert F. Bulleit; Ernest F. Zimmerman ABSTRACT The force for directing palate shelf reorientation appears to be associated with elements of the presumptive hard palate ( Brinkley & Vickerman, 1979 ; Bulleit & Zimmerman, 1985 ). The palatal elements that mediate this process do not require...

...Robert F. Bulleit; Ernest F. Zimmerman ABSTRACT The intrinsic forces necessary for directing the reorientation of the secondary palate appear to reside in the anterior two thirds of the palate or presumptive hard palate. The hard palate could reorient regardless of whether it was intact...