... regulatory circuitry of the pRb-E2F pathway (Fig. 1I). This result led us to hypothesize that mechanisms in addition to Rbf1 binding are used to control E2f1 activity in the early embryo. We found that E2f1 is destroyed during S phase of the post-blastoderm divisions in the embryonic epidermis...

...Woo Chi; Valerie Reinke In Caenorhabditis elegans , EFL-1 (E2F), DPL-1 (DP) and LIN-35(pRb) act coordinately in somatic tissues to inhibit ectopic cell division,probably by repressing the expression of target genes. EFL-1, DPL-1 and LIN-35 are also present in the germline, but do not always act...

... role for cki-1 Cip/Kip rather than lin-35 Rb explains the lack of cell-cycle phenotype of lin-35 mutant animals. *Author for correspondence (e-mail: [email protected]) 1 8 2001 © 2001. 2001 C. elegans Cyclin CDK pRb Cip/Kip Cell cycle The development...

... that the product of the retinoblastoma gene (pRb) may also be involved in this pathway. Previously, we have shown that TGF-β1 inhibits branching morphogenesis and N- myc expression in mouse embryonic lung cultures. The purpose of this study was to determine the role of pRb in the inhibition of branching...