..., disturbed XY-body formation and increased expression of the Y chromosome-encoded gene ZFY and seem to activate a DNA damage pathway leading to induction of p63, possibly causing spermatocyte apoptosis. Type II arrested spermatocytes display normal chromosome synapsis, normal XY-body morphology and meiotic...

... of p63 and limits H3K18ac at the p63 promoter. Corroborating the stratification defects, asymmetric cell divisions were virtually absent in Nir-deficient mice, suggesting that Nir is required for correct mitotic spindle orientation. In summary, our data define Nir as a key regulator of skin development...

... Stem cells Lineage differentiation P63 Estrogen receptor Mouse Stem cells are vital for adult tissue homeostasis and regeneration, and their deregulation plays a crucial role in human disease, notably cancer ( Reya et al., 2001 ). The mammary gland represents an ideal model system...

... Highlighted article : In the adult mouse lung, Notch3 identifies a population of parabasal cells and regulates the balance between basal and parabasal progenitor pools. Notch Basal cells p63 Airway differentiation Progenitor cells Lung regeneration Jagged COPD Basal cells are multipotent...

...Daisuke Suzuki; Raju Sahu; N. Adrian Leu; Makoto Senoo The transcription factor p63 (Trp63) plays a key role in homeostasis and regeneration of the skin. The p63 gene is transcribed from dual promoters, generating TAp63 isoforms with growth suppressive functions and dominant-negative ΔNp63 isoforms...

... and is a lineage-specific, developmentally regulated event controlled by transcription factor p63, a master regulator of epidermal development. We also show that, in epidermal progenitor cells, p63 directly regulates the expression of the ATP-dependent chromatin remodeller Brg1, which binds to distinct domains...

... from ectodermal progenitor cells are not well understood. Here, we use both developing mouse embryos and human embryonic stem cells (hESCs) to explore the mechanisms that direct keratinocyte fate from ectodermal progenitor cells. We show that both hESCs and murine embryos express p63 before keratin 14...

...Rose-Anne Romano; Kirsten Smalley; Caitlin Magraw; Vanida Ann Serna; Takeshi Kurita; Srikala Raghavan; Satrajit Sinha The transcription factor p63 is important in the development of the skin as p63 -null mice exhibit striking defects in embryonic epidermal morphogenesis. Understanding...

...Rose-Anne Romano; Kirsten Smalley; Song Liu; Satrajit Sinha The transcription factor p63 plays an essential role in epidermal morphogenesis. Animals lacking p63 fail to form many ectodermal organs, including the skin and hair follicles. Although the indispensable role of p63 in stratified...

.... SHFM-IV and Ectrodactyly-Ectodermal dysplasia-Cleft lip (EEC) are caused by mutations in p63 , an ectoderm-specific p53-related transcription factor. The similarity in the limb phenotype of different forms of SHFM may underlie the existence of a regulatory cascade involving the disease genes. Here, we...

..., and demonstrated the predominant expression of P-cadherin not only in the hair follicle placode, but also at the apical ectodermal ridge (AER) of the limb bud. Based on the evidence that mutations in the p63 gene also result in hypotrichosis and SHFM, and that the expression patterns of p63 and P-cadherin overlap...

... or western blot. The mutant esophagus morphologically resembles the trachea,with ectopic expression of Nkx2.1, a columnar, ciliated epithelium, and very few p63 + basal cells. By contrast, the abnormal foregut of Nkx2.1 -null embryos expresses elevated Sox2 and p63, suggesting reciprocal regulation of Sox2...

...-mesenchymal interactions during development. Dlx3 and p63 act as part of the transcriptional regulatory pathways relevant in ectoderm derivatives, and autosomal mutations in either of these genes are associated with human EDs. However, the functional relationship between both proteins is unknown. Here,we...

...Wei Cheng; W. Bradley Jacobs; Jennifer J. R. Zhang; Anne Moro; Jin-Hyung Park; Michelle Kushida; Wei Qiu; Alea A. Mills; Peter C. W. Kim The bladder, the largest smooth-muscle organ in the human body, is responsible for urine storage and micturition. P63, a homolog of the p53 tumor-suppressor gene...

...-negative form of p53 could inhibit OPC differentiation induced by TH but not by PDGF withdrawal, suggesting that the p53 family of proteins might play a part in TH-induced differentiation. As the dominant-negative p53 used inhibited all three known p53 family members - p53, p63 and p73 - it was uncertain...