... of retinal neurogenesis in zebrafish. Almost all retinal cells continue to proliferate when PKA is activated, suggesting that PKA inhibits the cell-cycle exit of retinoblasts. A cyclin-dependent kinase (cdk) inhibitor p27 inhibits the PKA-induced proliferation, suggesting that PKA functions upstream...

... is essential to prevent neuronal differentiation and promote cell proliferation in a medial compartment of the IZ. We identify one probable target of this activity, the zebrafish Cdk inhibitor p27 Xic1 . Finally, although the her5 expression domain is determined by anteroposterior patterning cues, we show Her5...

... and maintain these two independent cell cycles is unknown. We demonstrate a role for the p21 CIP /p27 Kip1 /p57 Kip2 -like cyclin-dependent kinase inhibitor (cki) dacapo in the maintenance of the meiotic cycle in Drosophila oocytes. Our data indicate that it is through the differential regulation of the cki...

... p27 Cell proliferation prospero G1 arrest Drosophila Unrestrained cell proliferation results in an exponential increase of cell numbers. An accurate regulation of cell proliferation is therefore required in particular in multicellular organisms where tissue-specific limits for cell...

... of neural bHLH proteins is sufficient to confer a neuronal fate on uncommitted mammalian cells. Neuronal differentiation of transfected cells is preceded by elevated expression of the cyclin-dependent kinase inhibitor p27 Kip1 and cell cycle withdrawal. This demonstrates that the bHLH proteins can link...