... based on whether doxycycline is absent or present, respectively. We also show that the approach can be extended to other animal models, using chicken embryos. We generated three mouse lines targeted at the Tigre ( Igs7 ) locus with TRE- loxP -tdTomato- loxP upstream of three genes ( p21 , DTA and Ctgf...

... these control mechanisms in the hyaloid vessels, a temporary vascular network in the mammalian eye that requires a Wnt/β-catenin response for scheduled regression. We investigated whether the hyaloid Wnt response was linked to the oncogene Myc , and the cyclin-dependent kinase inhibitor CDKN1A (P21), both...

...-terminus in mice leads to ectodermal malformation and hypoplasia, accompanied by a reduced proliferative capacity of epidermal progenitor cells. Notably, unlike the p63 -null condition, we find that p63 C-terminus deficiency promotes expression of the cyclin-dependent kinase inhibitor p21 Waf1/Cip1 (Cdkn1a...

... or the cdk inhibitor p21. By contrast,the ability of dMyc to promote growth and endoreplication is only partly reduced when PI3K activity is blocked, suggesting that they influence distinct growth pathways. Our results indicate that larval growth and endoreplication are coupled processes that, although...

... of the enamel knot have not been described. Here we report that the cessation of cell proliferation in the enamel knot in mouse molar teeth is linked with the expression of the cyclin-dependent kinase inhibitor p21 . We show that p21 expression is induced by bone morphogenetic protein 4 (BMP-4) in isolated...