... of ovarian germline cysts. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 26 7 2010 © 2010. 2010 Ataxin 2-binding protein 1 Drosophila Oogenesis Ovarian tumor...

... the sex chromosome constitution of the germ cells still plays some role at this time. The male soma signals to the germline through the JAK/STAT pathway, while the nature of the signal from the female soma remains unknown. We also find that the genes ovo and ovarian tumor ( otu ) are expressed in a female...

... suggest that ovo acts in the same regulatory network as ovarian tumor ( otu ), but the relative position of these genes in the pathway is controversial. Three OVO-binding sites exist in a compact regulatory region that controls germline expression of the otu gene. Interestingly, the strongest OVO-binding...

... early oogenesis. In particular, the sex-specific germline activity of the ovarian tumor promoter was found to be dependent upon somatic factors controlled by the somatic sex differentiation gene transformer . This regulation defines whether there is sufficient ovarian tumor expression in adult XX germ...

... in this interaction, we examined whether changes in the sexual identity of the soma affected the function of the ovarian tumor ( otu ) and ovo genes. These genes are required cell autonomously in the female germline for germ cell proliferation and differentiation. Mutations in otu and ovo cause a range of ovarian...

... ovarian tumor An important step in germ-line development, is the bifurcation leading to spermatogenesis or oogenesis. One of the principal inputs in both the germ-line and somatic sex determination hierarchies (reviewed by Burtis, 1993 ) involves counting the number of X chromosomes ( Schüpbach...

...Daniel Pauli; Brian Oliver; Anthony P. Mahowald ABSTRACT The locus ovarian tumor ( otu ) is involved in several aspects of oogenesis in Drosophila melanogaster . The possible role of otu in the determination of the sexual identity of germ cells has not been extensively explored. Some otu alleles...

... with the egg-specific GPI. Most of them were arrested during early cleavage divisions. Some embryos cleaved abnormally or mimicked normal embryogenesis. In a few instances, development resulted in embryos that resembled late preimplantation embryos. © 1990 by Company of Biologists 1990 ovarian tumor...