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Keywords: otx
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Journal Articles
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Neural development
Journal: Development
Development (2021) 148 (12): dev198754.
Published: 14 June 2021
... and the transcription factor Otx are required for the expression of Fer2 in the dopaminergic cell lineage. Our findings establish the cellular and molecular framework for fully understanding the commitment to dopaminergic cells in the simple chordate brain. The transcription factor Otx is essential...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev171405.
Published: 21 November 2019
... of ectopic pineal progenitors. We also demonstrate that fibroblast growth factors (FGFs) position the pineal progenitor domain within the non-neural border by repressing pineal fate and that the Otx transcription factors promote pinealogenesis by inhibiting this FGF activity. The non-neural origin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2792–2800.
Published: 15 August 2015
... of the cochlear duct shows a striking competence to develop into a mirror-image copy of the organ of Corti. Taken together, these data show that Otx2 acts downstream of N-myc and is essential for patterning and spatial restriction of the sensory domain of the mammalian cochlea. Inner ear Cochlea Otx Myc...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2003) 130 (11): 2365–2373.
Published: 1 June 2003
... and an intervening midbrain/hindbrain boundary region, which are characterized by the specific expression of the Otx, Hox and Pax2/5/8 genes, respectively. We show that the embryonic brain of the fruitfly Drosophila melanogaster expresses all three sets of homologous genes in a similar tripartite pattern. Thus...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1281–1294.
Published: 1 April 2003
... in the same way as the full-length proteins. This fits with a recent study that compares otd/Otx family members ( Sauka-Spengler et al., 2001 ) and the fact that Xenopus XOtx5b and XOtx2 have very similar homeodomains and N-terminal regions. Indeed, Xenopus XOtx5b and XOtx2 homeodomains (HD) have only one...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4393–4404.
Published: 15 November 2001
...., 1996 ). When SpOtx is converted to an active repressor by linking its DNA-binding domain to the engrailed repression domain and this protein is expressed in sea urchin embryos, accumulation of aboral ectoderm-specific markers is strongly suppressed ( Li et al., 1999 ). Because Otx and Gsc have been...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2433–2450.
Published: 1 July 2001
... of midbrain/hindbrain development, yet relatively little is known about forebrain organization. Nested expression among Otx and Emx genes has implicated their roles in rostral brain regionalization, but single mutant phenotypes of these genes have not provided sufficient information. In order to genetically...