... of the cochlea, reflecting the pattern of cell cycle exit. To understand SOX2 function, we undertook a timed-deletion approach, revealing that early loss of SOX2 severely impaired morphological development of the ear, whereas later deletions resulted in sensory disruptions. During otocyst stages, SOX2 shifted...

... after otocyst formation for maintenance of otic neuroblasts and for patterning and proliferation of the epithelium, leading to normal morphogenesis of both the cochlear and vestibular domains. Furthermore, the first genome-wide identification of proximal targets of FGFR2b signaling in the early otocyst...

...Sho Ohta; Baolin Wang; Suzanne L. Mansour; Gary C. Schoenwolf The inner ear consists of two otocyst-derived, structurally and functionally distinct components: the dorsal vestibular and ventral auditory compartments. BMP signaling is required to form the vestibular compartment, but how...

... – are orchestrated by gradients of signaling molecules. * Authors for correspondence ([email protected] ; [email protected]) Competing interests statement The authors declare no competing financial interests. © 2012. 2012 Otic placode Morphogen Inner ear Cochlea Otocyst...

... to a hair-cell fate. 19 9 2007 © 2007. 2007 Proneural gene bHLH Hair cells Inner ear Otocyst Neurogenesis During ear development, diverse components of a sensory pathway - neurons,mechanosensory hair cells, supporting cells and other non-sensory epithelial cells - derive from...

... and acoustic ganglia, revealing the presence of a common progenitor for the two functional classes of neurons. * Author for correspondence (e-mail: [email protected]) 1 2 2005 ©2005. 2005 Labyrinth Placode Otocyst Cell lineage Neuroblast Chick Mechanosensory systems...

...Steven Raft; Sonja Nowotschin; Jun Liao; Bernice E. Morrow Inner ear sensory organs and VIIIth cranial ganglion neurons of the auditory/vestibular pathway derive from an ectodermal placode that invaginates to form an otocyst. We show that in the mouse otocyst epithelium, Tbx1 suppresses neurogenin...

...Habib Maroon; Jennifer Walshe; Radma Mahmood; Paul Kiefer; Clive Dickson; Ivor Mason Fgf3 has long been implicated in otic placode induction and early development of the otocyst; however, the results of experiments in mouse and chick embryos to determine its function have proved to be conflicting...

... inner ear, BMP4 expression becomes localized in two cell clusters at the anterior and posterior edges of the otic epithelium beginning at stage 16/17 and is expressed in presumptive sensory tissue at later stages. This restricted spatiotemporal pattern of expression occurs just prior to the otocyst’s...

... apoptosis otocyst retrovirus epithelial fusion TUNEL bcl-2 The vertebrate inner ear arises from an epithelial thickening on the surface of the head that invaginates and pinches off to form an independent fluid-filled vesicle, called the otocyst (Alvarez and Navascués, 1990 ; Fritzsch et al...

... embryos to determine sites of possible functions of NGF or NGF-like molecules in inner ear development. NGFR expression in the chick otocyst and acoustic ganglion is compared with epithelial differentiation and the onset of afferent innervation as determined with fluorescent carbocyanine tracers...

...Joseph R. McPhee; Thomas R. Van De Water ABSTRACT The otocyst is the epithelial anlage of the membranous labyrinth which interacts with surrounding cephalic mesenchyme to form an otic capsule. A series of in vitro studies was performed to gain a better understanding of the epithelial–mesenchymal...