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Keywords: osteoporosis
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Journal Articles

Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model

Thuy Thanh To, P. Eckhard Witten, Joerg Renn, Dipanjan Bhattacharya, Ann Huysseune, Christoph Winkler
Journal: Development
Development (2012) 139 (1): 141–150.
https://doi.org/10.1242/dev.071035
Published: 1 January 2012
... diseases such as osteoporosis. In mammals, receptor activator of NF-κB ligand (Rankl) is a regulator of osteoclast formation and activation: its misexpression causes osteoclast stimulation and osteoporotic bone loss. Here, we report an osteoporotic phenotype that is induced by overexpression of Rankl...
View article titled, Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka <span class="search-highlight">osteoporosis</span> model
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Includes: Multimedia, Supplementary data
Journal Articles

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

Chikara Kokubu, Ulrich Heinzmann, Tomoko Kokubu, Norio Sakai, Takuo Kubota, Masanobu Kawai, Matthias B. Wahl, Juan Galceran, Rudolf Grosschedl, Keiichi Ozono, Kenji Imai
Journal: Development
Development (2004) 131 (21): 5469–5480.
https://doi.org/10.1242/dev.01405
Published: 1 November 2004
... phenotype in adults. Together, we propose that Lrp6 is one of the key genetic components for the pathogenesis of vertebral segmentation defects and of osteoporosis in humans. References Aulehla, A., Wehrle, C., Brand-Saberi, B., Kemler, R., Gossler,A., Kanzler, B. and Herrmann, B. G. ( 2003 ). Wnt3a...
View article titled, Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
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Includes: Supplementary data
Journal Articles

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

Carol B. Ware, Mark C. Horowitz, Blair R. Renshaw, Joan S. Hunt, Denny Liggitt, Simon A. Koblar, Brian C. Gliniak, Hilary J. McKenna, Thalia Papayannopoulou, Bettina Thoma, Linzhao Cheng, Peter J. Donovan, Jacques J. Peschon, Perry F. Bartlett, Cynthia R. Willis, Barbara D. Wright, Melissa K. Carpenter, Barry L. Davison, David P. Gearing
Journal: Development
Development (1995) 121 (5): 1283–1299.
https://doi.org/10.1242/dev.121.5.1283
Published: 1 May 1995
... * Present address: SyStemix, 3155 Porter Dr., Palo Alto, CA 94304, USA 08 02 1995 © 1995 by Company of Biologists 1995 osteoporosis astrocytes glycogen store primordial germ cell mouse Heterodimerization of low-affinity LIFR with gp130 is required for the biological...
View article titled, Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
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