... of bone-forming osteoblasts and bone-resorbing osteoclasts at periosteal and endosteal surfaces, a process we designate trans -pairing. Two types of trans -pairing shift cortical bone in opposite orientations: peri-forming trans -pairing (peri- t -p) increases bone marrow space and endo-forming trans...

... effect treatment, P <0.05). Histological analysis at 11 DPA and 14 DPA showed that wound closure, blastema formation and regeneration are delayed in F-Clo-treated digits ( Fig. 5 G). To address the hypothesis that regeneration is dependent on osteoclasts and bone degradation, we took advantage...

...Thuy Thanh To; P. Eckhard Witten; Joerg Renn; Dipanjan Bhattacharya; Ann Huysseune; Christoph Winkler Osteoclasts are macrophage-related bone resorbing cells of hematopoietic origin. Factors that regulate osteoclastogenesis are of great interest for investigating the pathology and treatment of bone...

... differentiation markers reveals that En1 function is required for both early and late phases of calvarial osteogenesis. Further analysis shows that EN1 regulates FGF signaling in calvarial osteoblasts. Moreover, EN1 indirectly influences calvarial osteoclast recruitment and bone resorption by regulating...

..., these animals are distinguished by an excessive lysosomal storage in macrophages of the liver, spleen, bone marrow, kidney and by altered growth plates. Microscopic analyses showed an accumulation of osteopontin adjacent to actively resorbing osteoclasts of Acp5- and LAP/Acp5-deficient mice. In osteoclasts...

... by apoptosis. Apoptotic cells, presumably osteoclasts, were also located on the surfaces of the developing alveolar bone. When dissected E13 dental epithelium or mesenchyme were cultured in isolation, apoptotic cells were abundant throughout the tissues, whereas when cultured together, apoptosis was inhibited...