... of optic nerve (3 mm distally from the ONC site) (B), and retrogradely transported via the regenerated axons into the RGC soma located in the retina (C). Twelve hours later, animals were sacrificed (A) either for histological analysis, or live RGCs were isolated by Thy1 immunopanning and FACS carried out...

... of the optic nerve. Genetic evidence further supports that the formation of an Frs2α-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling in this process, whereas constitutively active Ras signaling can rescue ocular coloboma in the FGF signaling mutants. Our results thus...

... in the neuroepithelium. We investigated the guidance mechanisms of glial precursor (GP) cell migration in the optic nerve. GP cell migration in newborn rat optic nerve was monitored by the UV-thymine-dimer (TD) method. A double labeling study using NG2 and TD revealed that many of these in vivo migrating cells were NG2...

...Dietmar Schmucker; Herbert Jäckle; Ulrike Gaul ABSTRACT The Drosophila larval optic nerve, called Bolwig’s nerve (BN), projects into the central brain along a simple invariant path. The growth of the BN proceeds in three phases, during which the nerve changes direction at two intermediate targets...

...Hardeep S. Mudhar; Richard A. Pollock,; Chiayeng Wang; Charles D. Stiles; William D. Richardson ABSTRACT We have used in situ hybridization to visualize cells in the developing rat retina and optic nerve that express mRNAs encoding the A and B chains of platelet-derived growth factor (PDGF...

...Guus Wolswijk; Peter N. Riddle; Mark Noble ABSTRACT We have studied the developmental appearance of the O-2A adult progenitor cell, a specific type of oligodendro cyte-type-2 astrocyte (O-2A) progenitor cell that we have identified previously in cultures prepared from the optic nerves of adult rats...

...Guus Wolswijk; Mark Noble ABSTRACT We have found that glial progenitor cells isolated from the optic nerves of adult rats are fundamentally different from their counterparts in perinatal animals. In our studies on bipotential oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells, we have seen...

...J. S. H. Taylor ABSTRACT This study concerns the retinotopic organization of the ganglion cell fibres in the visual system of the frog Xenopus laevis . HRP was used to trace the pathways taken by fibres from discrete retinal positions as they pass from the retina, along the optic nerve...

... regeneration optic nerve fibre interactions Xenopus After surgical interruption of an amphibian optic nerve the fibres can regenerate to give a normal retinotectal projection. It has been suggested that the regenerating fibres are grossly disordered at the site of the lesion...