.... Summary: Using the fruit fly egg chamber as a model, this study demonstrates that the size and scaling of germline intercellular bridges vary based on lineage. Oogenesis Drosophila Intercellular bridge Ring canal National Institutes of Health R15HD084243 R15GM099054...

... synthesis. Overexpression of a methylation-deficient eRF1 variant recapitulates the defects observed in hemK2 -GLKD, suggesting that eRF1 is a primary methylation target of HemK2. Furthermore, hemK2 -GLKD leads to a significant reduction in mRNA levels in germline cell. These defects in oogenesis...

... in primordial germ cells in both sexes, but was maintained only during oogenesis and was destabilized in differentiating spermatogonia under the influence of Sertoli cells expressing dmrt1 . Although foxl3 was dispensable for this pathway, dazl was involved in the persistence of the microtubule dome at the time...

... obesity, high glycogen and trehalose levels, and fat body insulin resistance. These findings demonstrate that a high-sugar diet affects specific processes in oogenesis independently of insulin resistance, that high glucose levels correlate with reduced fertility on a high-sugar diet, and that obesity...

... and morphogenesis Live manipulation by laser-ablation Microscopy image analysis Oogenesis Germline cyst Zebrafish ovary Israel Science Foundation http://dx.doi.org/10.13039/501100003977 Hebrew University of Jerusalem http://dx.doi.org/10.13039/501100003483 Oogenesis...

... Drosophila oogenesis, LD accumulation coincides with the actin remodeling necessary for follicle development. Loss of the LD-associated Adipose Triglyceride Lipase (ATGL) disrupts both actin bundle formation and cortical actin integrity, an unusual phenotype also seen when the prostaglandin (PG) synthase Pxt...

...Travis T. Parsons; Sheila Mosallaei; Laurel A. Raftery ABSTRACT During Drosophila oogenesis, somatic follicle cells (FCs) differentiate to secrete components of the eggshell. Before secretion, the epithelium reorganizes to shape eggshell specializations, including border FC collective cell...

... mutants of nanog (M nanog ) in zebrafish, we demonstrated that Nanog tightly controls translation of maternal mRNA during oogenesis via transcriptional repression of eukaryotic translation elongation factor 1 alpha 1, like 2 ( eef1a1l2 ). Loss of maternal Nanog led to defects of egg maturation, increased...

.... A. and Rajkovic , A. ( 2006 ). Transcriptional regulation of early oogenesis: in search of masters . Hum. Reprod. Update 12 , 65 - 76 . 10.1093/humupd/dmi033 Popow , J. , Englert , M. , Weitzer , S. , Schleiffer , A. , Mierzwa , B. , Mechtler , K. , Trowitzsch , S...

...Gregory Logan; Wei-Chien Chou; Brooke M. McCartney ABSTRACT Cells reposition their nuclei for diverse specialized functions through a wide variety of cytoskeletal mechanisms. During Drosophila oogenesis, 15 nurse cells connected by ring canals to each other and the oocyte contract, ‘dumping...

... oogenesis using the model insect Drosophila melanogaster . In adult females maintained at 18°C (cold) or 29°C (warm), relative to females at the 25°C control temperature, egg production was reduced through distinct cellular mechanisms. Chronic 18°C exposure improved germline stem cell maintenance, survival...

... mouse oocyte transcription network, including reproduction and chromatin genes, through unexpected promoter localization of TAF4b at Sp/Klf- and NFY-binding sites. Transcription Oogenesis Oocytes Meiosis I TFIID TAF4b POI Fetal oocyte attrition Mouse National Institute of Child...

... ( Campbell and Tomlinson, 1999 ; Minami et al., 1999 ), which, in addition to other mechanisms, helps shape the Dpp gradient ( Affolter et al., 2001 ; Müller et al., 2003 ; O'Connor et al., 2006 ). Brk acts similarly in the ovaries starting at stage 8 of oogenesis when it is important for establishing...

...-oogenesis. Loss of Fra in the germline, but not the somatic cells of the ovary, results in the degeneration of egg chambers. Although a failure in nutrient sensing and disruptions in egg chamber polarity can result in degeneration at mid-oogenesis, these factors do not appear to be affected in fra germline...

... challenges associated with imaging and image processing. Here, we present a supervised learning approach for quantifying the growth dynamics of germline cysts during oogenesis. Our analysis uncovers growth patterns induced by the groupwise developmental dynamics among connected cells, and differential growth...

....2004.07.019 Lei , L. and Spradling , A. C. ( 2013 ). Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles . Proc. Natl. Acad. Sci. USA 110 , 8585 - 8590 . 10.1073/pnas.1306189110 Li , L. , Ji , S. Y. , Yang , J. L...

...Lesley N. Weaver; Daniela Drummond-Barbosa ABSTRACT The conserved nuclear receptor superfamily has crucial roles in many processes, including reproduction. Nuclear receptors with known roles in oogenesis have been studied mostly in the context of their ovary-intrinsic requirement. Recent studies...

... is essential for development. During late stages of Drosophila melanogaster oogenesis, the small somatic follicle cells that surround the large nurse cells promote non-apoptotic nurse cell death, subsequently engulf them, and contribute to the timely removal of nurse cell corpses. Here, we identify a role...

...Anne E. Smolko; Laura Shapiro-Kulnane; Helen K. Salz ABSTRACT Maintenance of germ cell sexual identity is essential for reproduction. Entry into the spermatogenesis or oogenesis pathway requires that the appropriate gene network is activated and the antagonist network is silenced. For example...

... developmental biologists can make unique and valuable contributions to the field of metabolism and physiology. Warburg effect Human disease Metabolism Inter-organ communication Oogenesis Drosophila National Institute of General Medical Sciences 10.13039/100000057 R01 GM125121...