... specification. A missense mutation in a conserved extracellular residue, Ser642, adjacent to the transmembrane domain, is sufficient to confer the glp-1(oz112gf) mutant phenotypes. Two mammalian Notch family members, TAN-1 and int-3 , are proto-oncogenes. Thus, activating mutations in both invertebrate...

... layer cells, by infection with a retrovirus containing the SV40 large T-antigen oncogene, gave rise to several cerebellar cell types upon implantation. These included granule neurons, one subclass of stellate interneurons, Golgi cells, Bergmann glia and astrocytes. From these results, we conclude...

...-oncogene oncogene Drosophila development gene expression Multicellular organisms possess many protein-tyrosine kinases (PTKs) that serve a variety of functions in the determination of cellular phenotype ( Hunter and Cooper, 1985 ). These enzymes fall into two broad classes, those that span...

...Peter D. Vize; Ashley Vaughan; Paul Krieg The N-myc proto-oncogene is expressed in a wide range of tissues during mammalian embryogenesis. This observation, along with the oncogenic capacity of this gene, has led to the suggestion that N-myc plays an important role in early development. However...

...B. Vandenbunder; L. Pardanaud; T. Jaffredo; M. A. Mirabel; D. Stehelin ABSTRACT We have used in situ hybridization to study the spatial and temporal distribution of the transcription of three cellular oncogenes encoding DNA-binding proteins, c-ets 1, c-myb and c-myc during the development...

... = 15 000. This molecule is immunologically related to the protein product of the human K-FGF proto-oncogene. Transcripts derived from the murine K-FGF gene are also expressed by both differentiated and undifferentiated EC cells and embryonic stem cells. The second heparin-binding growth factor...

...Eileen D. Adamson © 1987 by Company of Biologists 1987 oncogene Realization that the transforming oncogenes (v-onc) of the acutely oncogenic retroviruses are homologous to cellular genes (and were probably derived from them) brought several areas of research together...