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Keywords: nodal
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (9): dev197111.
Published: 28 April 2021
... cells failing to express NANOS2. Single-cell RNA sequencing revealed that embryonic day 15.5 NANOS2-deficient germ cells and embryonal carcinoma cells developed a transcriptional profile enriched for MYC signaling, NODAL signaling and primed pluripotency. Moreover, lineage-tracing experiments...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev188490.
Published: 12 March 2021
... with Nodal ligands to facilitate their interaction with ACVR1B; neuropilin associates with TGFBR1 to promote downstream signaling; endoglin may bind to BMP ligands or to BMPR2 receptors to facilitate signaling, and may also associate with TGFβ1 or TGFβ3 for signaling through ACVRL1; and the repulsive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
...Olga Ossipova; Keiji Itoh; Aurelian Radu; Jerome Ezan; Sergei Y. Sokol ABSTRACT Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev186965.
Published: 14 August 2020
.... The mechanisms that prevent endoderm cell division, trigger the transition between step 1 and step 2, and drive apico-basal shortening have remained elusive. Here, we demonstrate a conserved role for Nodal and Eph signalling during invagination in two distantly related ascidian species, Phallusia mammillata...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev170985.
Published: 15 August 2019
... be generated alongside each other in the embryo and then maintained during growth. Symmetry Asymmetry Nodal Left-right Limbs Somites Cilia The vast majority of animals have body plans based on bilateral symmetry. They possess orthogonal anterior-posterior (A-P) and dorsal-ventral (D-V) axes...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev171090.
Published: 10 December 2018
...Tessa G. Montague; James A. Gagnon; Alexander F. Schier ABSTRACT Nodal is the major effector of left-right axis development. In mice, Nodal forms heterodimers with Gdf1 and is inhibited by Cerl2/Dand5 at the node, and by Lefty1 in the lateral plate mesoderm (LPM). Studies in zebrafish have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev158832.
Published: 06 March 2018
... in space and time, the molecular mechanisms underlying the loss of competence remain largely unknown. Here, we determine the time window during which zebrafish prospective ectoderm loses its ability to respond to Nodal signals, and show that this coincides with a decrease in the levels of the Nodal co...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev155663.
Published: 22 January 2018
... and then in the left side of the embryo where the germ cells form a posterior enterocoel. We find that Nodal signaling is required for the restriction of two germ cell factors, Nanos and Vasa, during the early development of this animal. We learned that Nodal inhibits germ cell factor accumulation in three ways...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 4015–4025.
Published: 01 November 2017
..., which comprises extraembryonic tissue, occurs in the first cells fated to differentiate into the endoderm. Nodal signaling is essential for nuclear movement, whereas nuclear envelope proteins are involved in movement through microtubule formation. Positioning of the microtubule-organizing center, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2270–2281.
Published: 15 June 2017
...Maria Dolores Molina; Magali Quirin; Emmanuel Haillot; Felipe Jimenez; Aline Chessel; Thierry Lepage Dorsal-ventral axis formation in the sea urchin embryo relies on the asymmetrical expression of the TGFβ Nodal. The p38-MAPK pathway has been proposed to be essential for dorsal-ventral axis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (2): 345–355.
Published: 15 January 2017
... be used to resolve multiple roles of Nodal signaling at different stages of embryonic development. Finally, we show how inducible gene editing can be achieved by combining the TAEL and CRISPR/Cas9 systems. This toolkit should be a broadly useful resource for the fish community. * Present address...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4665–4675.
Published: 15 December 2016
...Ignacio A. Navarrete; Michael Levine Formation of the vertebrate neural tube represents one of the premier examples of morphogenesis in animal development. Here, we investigate this process in the simple chordate Ciona intestinalis . Previous studies have implicated Nodal and FGF signals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (22): 3821–3832.
Published: 15 November 2015
... of the ventral forebrain. Currently little is known about how Shh is regulated in prechordal tissue. Here we show that in the embryonic chick, Shh is expressed transiently in prechordal mesoderm, and is governed by unprocessed Nodal. Exposure of prechordal mesoderm microcultures to Nodal-conditioned medium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (4): 607–619.
Published: 15 February 2015
...Siim Pauklin; Ludovic Vallier Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell...
Journal Articles
Journal: Development
Development (2014) 141 (20): 3889–3899.
Published: 15 October 2014
... that HrBMPa (60A-subclass BMP) and HrBMPb ( dpp -subclass BMP) act to induce trunk ESNs at the tailbud stage and that anterior trunk ESN specification requires Chordin-mediated antagonism of the BMP signal, but posterior trunk ESN specification does not. We also found that Nodal functions as a neural plate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1572–1579.
Published: 01 April 2014
... and connectivity. The Nodal target pitx2c is expressed in the left epithalamus, but nothing is known about its role during the establishment of asymmetry in the brain. We show that abrogating Pitx2c function leads to the right habenula adopting aspects of left character, and to an increase in parapineal cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4465–4470.
Published: 15 November 2013
... declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Asymmetry Cilia Left-right asymmetry Left-right axis Morphogenesis Nodal Since one of the earliest accounts of a left-right (LR) patterning defect in the literature...
Journal Articles
Journal: Development
Development (2013) 140 (22): 4533–4543.
Published: 15 November 2013
... a transient region in the anterior-proximal side of the embryo at E7.0 that possesses the ability to become neural or epidermal ectoderm in response to the absence or presence of BMP4, respectively. Furthermore, we demonstrated that inhibition of Nodal signaling could direct the pluripotent E6.5 epiblast...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1819–1829.
Published: 15 April 2013
..., the current study identifies and characterizes Vg1/Nodal signaling (henceforth referred to as ‘Nodal-like signaling’) as a novel regulator of IM formation. Excess Nodal-like signaling at gastrulation stages resulted in expansion of the IM at the expense of the adjacent paraxial mesoderm, whereas inhibition...
Journal Articles
Journal: Development
Development (2013) 140 (5): 976–986.
Published: 01 March 2013
... signals. The development of axial and paraxial mesoderm is severely abnormal in lin28 knockdown (morphant) embryos. In culture, the ability of pluripotent cells from the embryo to respond to the FGF and activin/nodal-like mesoderm-inducing pathways is compromised following inhibition of lin28 function...
Includes: Supplementary data