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Keywords: nkx2.5
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Journal Articles
Journal: Development
Development (2018) 145 (3): dev161497.
Published: 5 February 2018
... transcription factor is a central regulator of cardiac development and is expressed in both the first and second heart fields (FHF and SHF). We have previously revealed essential functions of nkx2.5 and nkx2.7 , two Nkx2-5 homologs expressed in zebrafish cardiomyocytes, in maintaining ventricular identity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4616–4624.
Published: 15 December 2017
... outflow tract (OFT). In zebrafish, previous lineage-tracing and mutant analyses suggested that SHF ventricular and OFT progenitors co-migrate to the arterial pole of the zebrafish heart tube soon after their specification in the nkx2.5 + field of anterior lateral plate mesoderm (ALPM). Using additional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1328–1338.
Published: 1 April 2017
... of cardiomyocytes in the ventricle, clearly outside of the normal domain of amhc expression ( Fig. 1 B,F). (Here, we will refer to these as ‘ectopic amhc -expressing cells’.) This scenario is reminiscent of the phenotype of nkx2.5 mutants, which initially exhibit normal expression patterns of amhc and vmhc...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4203–4213.
Published: 15 October 2013
... and maintaining unique features in ventricular and atrial cardiomyocytes, the regulatory mechanisms guiding these processes are poorly understood. Here, we show that the homeodomain transcription factors Nkx2.5 and Nkx2.7 are necessary to sustain ventricular chamber attributes through repression of atrial chamber...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (6): 1353–1363.
Published: 15 March 2013
... lineage traced gata4 + and nkx2.5 + ALPM populations predicted to contain SHF progenitors, based on evolutionary conservation of ALPM patterning. Traced cells were identified in SHF-derived distal ventricular myocardium and in three lineages in the outflow tract (OFT). We confirmed the extent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3235–3245.
Published: 1 August 2011
... be via suppression of the haemangioblast programme. However, we show that the cardiac regulator nkx2.5 can also repress the haemangioblast programme and, furthermore, that cardiac specification still requires Fgf signalling even when haemangioblast regulators are independently suppressed. We further show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (20): 4073–4083.
Published: 15 October 2006
...Stéphane Zaffran; Ingolf Reim; Li Qian; Patrick C. Lo; Rolf Bodmer; Manfred Frasch The NK homeobox gene tinman ( tin ) is required for the specification of the cardiac, visceral muscle and somatic muscle progenitors in the early dorsal mesoderm of Drosophila. Like its vertebrate counterpart Nkx2.5...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3305–3316.
Published: 15 July 2005
... the synergistic activity of key cardiac transcription factors, Nkx2.5 and Tbx5, leading to reduced activation of the common target gene, Anf ( Nppa ). Strikingly, reduced levels of Anf expression were also observed in embryonic day 9.5 Carp-Lbh transgenic mice. Thus, repression of Nkx2.5 and Tbx5-mediated gene...
Journal Articles
Journal: Development
Development (2005) 132 (13): 3113–3126.
Published: 1 July 2005
... (Tlx1), Nkx3.2 (Bapx1) and Pod1 (capsulin, Tcf21). We show that Hox11 and Nkx2.5 , among the earliest known markers for splenic progenitor cells, are absent in the splenic anlage of Pbx1 homozygous mutant ( -/- ) embryos, implicating the TALE homeoprotein Pbx1 in splenic cell specification. Pbx1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4709–4723.
Published: 1 October 2004
... of key cardiac regulators, we have characterized the cis-regulatory elements of the chick tinman homolog chick Nkx2.5 . We find that at least three distinct cardiac activating regions (CARs) of chick Nkx2.5 cooperate to regulate early expression in the cardiac crescent and later segmental expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (9): 2219–2231.
Published: 1 May 2004
... required for maintaining normal expression levels of several key cardiogenic factors (e.g. NKX2.5 and MEF2C) in the developing myocardium at mid-gestation. Furthermore, BMP10-conditioned medium is able to rescue BMP10-deficient hearts in culture. Our data suggest an important pathway that involves...
Journal Articles
Journal: Development
Development (2001) 128 (12): 2269–2279.
Published: 15 June 2001
... drawn in studies based on these maps. We present accurate fate maps of the heart-forming region (HFR) in avian embryos and show that the putative cardiogenic molecular markers Bmp2 and Nkx2.5 do not govern the boundaries of the HFR as suggested in the literature. Moreover, this paper presents the first...