... an overview of salamanders as a model system for studying regeneration, outlining the mechanisms deployed during salamander regeneration and highlighting how the study of salamanders has increased our understanding of regeneration more broadly. CNS Axolotl Genome Limb Model organism Newt...

... Neurogenesis Brain development Behavior Evolution Pleurodeles Notophthalmus Newt Vetenskapsrådet 10.13039/501100004359 Hjärnfonden 10.13039/501100003792 Cancerfonden 10.13039/501100002794 Wenner-Gren Foundation 10.13039/100001388 Karolinska...

... 2007. 2007 Neurogenesis Newt Regeneration 6-hydroxydopamine Behaviour Dopamine Parkinson's disease One candidate treatment for Parkinson's disease is cell replacement therapy. Embryonic stem cells have been found to differentiate into dopaminergic (DA) neurons capable of integrating...

... monoclonal antibody LP1K reacts strongly with newt blastemal cells, while its reactivity is restricted in normal limbs. By screening a cDNA expression library from the newt blastema with LP1K, we have identified cDNA clones coding for a type II keratin (NvKH) expressed both in the mesenchyme...

...Kevin J. P. Griffin; Donna M. Fekete; Bruce M. Carlson ABSTRACT Monoclonal antibodies have been used to study minced muscle regeneration in the adult newt, Notophthalmus viridescens . The contralateral limb was amputated and the immunostaining patterns in the regenerating blastema were compared...

...David J. Goldhamer; Roy A. Tassava ABSTRACT Pulse and continuous labelling with [ 3 H]thymidine combined with mitotic index determinations provided data on the kinetics of cell cycling in innervated and denervated early and mid-bud forelimb blastemas of the adult newt, Notophthalmus viridescens...

...H. Wallace Crested newts exhibit a balanced lethal system which causes development to abort in 50 % of tailbud embryos. The main features of arrested embryos are described, shown to be constant in a range of culture conditions and found to be unchanged by parabiosis or extirpation of the central...

...Donna M. Fekete; Jeremy P. Brockes We have previously described a monoclonal antibody (called 22/18) that reacts with the early blastemal cells of the regenerating limb of the newt (Notophthal-mus viridescens) . In embryos of two newt species the antibody reacts with the epidermis, glial cells...

... synthesis and/or mitosis but sustained cell cycle activity and blastema development have not been achieved. Because dorsal root ganglia (DRG) implants are capable of promoting regeneration of denervated adult newt limbs ( Kamrin & Singer, 1959 ), we have evaluated the DRG stimulation of regeneration...

...Hiromasa Ohshima; Tomoyuki Kubota ABSTRACT Scanning electron microscopic studies were carried out on changes of the cell surface during the first cleavage of eggs of the newt, Cynopus (Triturus) pyrrhogaster . A dense population of elongated microvilli, which initially covered a double line...