... indispensable for central nervous system formation in vertebrates. Apical constriction Convergent extension Morphogenesis Neural tube closure Neurulation Xenopus European Regional Development Fund http://dx.doi.org/10.13039/501100008530 Research and Innovation Foundation...

... of these factors on gastrulation and neurulation. Thus, we generated a conditional expression system by cloning dlx4b and flh/noto into heat shock-inducible plasmids that drive the expression of green fluorescent protein (GFP)-tagged versions of these two genes ( Lewis et al., 2004 ). Embryos injected...

...Evanthia Nikolopoulou; Gabriel L. Galea; Ana Rolo; Nicholas D. E. Greene; Andrew J. Copp Neural tube closure has been studied for many decades, across a range of vertebrates, as a paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the severe congenital...

...://www.biologists.com/user-licence-1-1/ Summary: Live imaging of neural tube morphogenesis in Ciona uncovers roles for FGF and Nodal signaling in controlling the intercalation and stacking behaviors of cells. FGF Nodal Neurulation Morphogenesis Ascidian Intercalation National Institutes...

...Yosuke Ogura; Asako Sakaue-Sawano; Masashi Nakagawa; Nori Satoh; Atsushi Miyawaki; Yasunori Sasakura Chordates undergo a characteristic morphogenetic process during neurulation to form a dorsal hollow neural tube. Neurulation begins with the formation of the neural plate and ends when the left...

... to target their expression in descendants of specific blastomeres. * Author for correspondence (e-mail: [email protected] ) 16 2 2009 © 2009. 2009 Xenopus Actin Cadherin Morphogenetic movement Neurulation Morphogenetic tissue movements control both...

.... If dorsolateral bending fails, spina bifida results. In the present study, we investigated the molecular signals that regulate the formation of dorsolateral hinge points (DLHPs). We show that Bmp2 expression correlates with upper spinal neurulation (in which DLHPs are absent); that Bmp2 -null embryos exhibit...

... embryonic midline prevents the onset of neurulation through wide spacing of the neural folds. In order to evaluate the role of convergent extension in this defect, we vitally labelled the midline of loop-tail ( Lp ) embryos mutant for the PCP gene Vangl2 . Injection of DiI into the node, and electroporation...

...Samantha J. England; Guy B. Blanchard; L. Mahadevan; Richard J. Adams Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while...

... have shown previously that mammalian PCP homologs regulate both cell polarity and polarized extension in the cochlea in the mouse. Here we show, using mice with null mutations in two mammalian Dishevelled homologs, Dvl1 and Dvl2 , that during neurulation a homologous mammalian PCP pathway regulates...

... gastrulation and neurulation suggests functions in early development of the central nervous system. We have functionally analysed the role of Xenopus Gpc4 by using antisense morpholino oligonucleotides and show that Gpc4 is part of the signalling network that patterns the forebrain. Depletion of GPC4 protein...

... Probes) was used according to the manufacturer's protocol. To visualise F-actin, embryos were incubated in rhodamine-conjugated phalloidin (Molecular Probes). The following is a short description of neurulation in the zebrafish at the level of the first to fifth somite (prospective cervical spinal...

...John B. Wallingford; Richard M. Harland In Xenopus , Dishevelled (Xdsh) signaling is required for both neural tube closure and neural convergent extension, but the connection between these two morphogenetic processes remains unclear. Indeed normal neurulation requires several different cell...

...Patricia Ybot-Gonzalez; Patricia Cogram; Dianne Gerrelli; Andrew J. Copp Neural tube closure is a fundamental embryonic event whose molecular regulation is poorly understood. As mouse neurulation progresses along the spinal axis, there is a shift from midline neural plate bending to dorsolateral...

... markers, Hesx1, Six3 and Fgf8 . These findings indicate a requirement of the rostral AML for the patterning of the forebrain neural precursors during neurulation. The ablation of the rostral segment of the AML may also have removed the anterior neural ridge (ANR) precursor cells at the junction...

...Jean-Baptiste Charrier; Marie-Aimée Teillet; Françoise Lapointe; Nicole M. Le Douarin Hensen’s node, also called the chordoneural hinge in the tail bud, is a group of cells that constitutes the organizer of the avian embryo and that expresses the gene HNF-3 β? During gastrulation and neurulation...

... Forest, IL 60045, USA 17 03 1999 04 05 1999 © 1999 by Company of Biologists 1999 Blastoderm Epiblast Gastrulation Hensen’s node In situ hybridization Neural plate Neural tube Neurulation Organizer Primitive streak Quail/chick chimera It is conceivable...

... of mesoderm movement and fate during avian gastrulation and neurulation . Dev. Dynam . 193 , 249 – 256 . 10.1002/aja.1001930305 Garcia-Martinez , V. and Schoenwolf , G. C. ( 1993 ). Primitive-streak origin of the cardiovascular system in avian embryos . Dev. Biol . 159 , 706 – 719...

.... Expression of Nxfz8 in dorsal cells has profound effects on morphogenesis during gastrulation and neurulation that result in dramatic shortening of the anterior-posterior axis. Our results suggest a role for xfz8 in morphogenesis during the gastrula stage of embryogenesis. For histology, embryos were fixed...

... with changes in tissue morphology associated with neurulation. * Author for correspondence (e-mail: [email protected] ) 17 02 1998 06 01 1998 © 1998 by Company of Biologists 1998 Morphogenesis Cell movement Cell division Cell shape Epiblast Ectoderm Neural...