... Neuronal development Neuroscience National Institute of Mental Health http://dx.doi.org/10.13039/100000025 R01MH119157 National Institute of Neurological Disorders and Stroke http://dx.doi.org/10.13039/100000065 R03NS101524 University of Wisconsin-Milwaukee http...

... developments in single-cell mRNA sequencing and machine learning algorithms to define neuronal developmental trajectories. In vitro differentiation Machine learning Neuronal development Neuronal differentiation protocols Neuronal replacement therapy Single-cell sequencing The goal...

... targets of SET-2 will help to clarify the specific mechanism underlying the genetic interactions observed. Despite the recognition of H3K4 methylation as a crucial epigenetic modification in neuronal development, its biological role in this tissue is only marginally understood ( Mariani et al., 2016...

... cadherins Motor neuron Adhesion Migration Neuronal development Summary: In mouse, type II cadherins control the organization of motor neurons into pools by functional interaction with N-cadherin rather than via the implementation of an adhesive code. © 2019. Published by The Company...

...Alba Redo Riveiro; Luca Mariani; Emily Malmberg; Pier Giorgio Amendola; Juhani Peltonen; Garry Wong; Anna Elisabetta Salcini Components of the KDM7 family of histone demethylases are implicated in neuronal development and one member, PHF8, is often found to be mutated in cases of X-linked mental...

... protein and member of the chromatin-remodeling complex NURF, is required for promoting aberrant wsp-1 transcription in rbr-2 mutants and its ablation restores wild-type expression of wsp-1 and axon guidance. Thus, our results establish a precise role for epigenetic regulation in neuronal development...

... The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Imprinted genes Fetal growth DNA methylation Induced pluripotency Behavior Neuronal development Mammals inherit two sets of chromosomes, one from each parent, and therefore...

... ). Cellular and molecular determinants of sympathetic neuron development . Annu. Rev. Neurosci. 22 , 541 - 566 . Gammie S. C. , Truman J. W. ( 1997 ). Neuropeptide hierarchies and the activation of sequential motor behaviors in the hawkmoth, Manduca sexta . J. Neurosci. 17 , 4389...

... Competing interests statement 25 3 2010 © 2010. C. elegans Left/right asymmetry Neuronal development Transcriptional control Drosophila Groucho, C. elegans UNC-37 and their four vertebrate orthologs Tle1-4 (Grg1-4) are WD40 domain-containing co-repressors...

... trajectories through the amphid commissure and the ventral nerve cord. Axon guidance C. elegans Neuronal development Wnt signaling © 2009. 2009 16 9 2009 * Author for correspondence( [email protected] ) References Adler, C. E., Fetter, R. D. and Bargmann, C. I...

... is also required for many other neurons of diverse lineage history and function to appropriately differentiate,illustrating the broad and diverse use of this type of transcription factor in neuronal development. * Author for correspondence( [email protected] ) 30 6 2009 © 2009. © 2009...

... and diverse cis-regulatory control mechanisms and we show that the affinity of CHE-1 to its binding site plays a role in controlling L/R asymmetric gene expression programs. Fig. 1. Models for ASE neuron development and the establishment of left/right asymmetric gene expression profiles...

... by cells of the optic lobes allows the Fasciclin II-expressing larval visual organ cells to detach from the optic lobes as a cohesive cell cluster. Our results also demonstrate that mechanisms guiding neuronal development may be shared between motoneurons and sensory organs, and provide evidence...

... apoptosis may be regulated by modulating Bax levels and that Bax-induced death requires caspase activity. * Author for correspondence (e-mail: [email protected] ) 22 01 1997 © 1997 by Company of Biologists 1997 apoptosis Bax Bcl-x neuronal development cell death nervous system...

... in muscle-specific degeneration. 103 mutations, defining at least 30 genes, cause no obvious defects in muscle formation and may instead affect neuronal development. Analysis of the behavioral defects suggests that these genes participate in the diverse loco-motion patterns observed, such as touch response...

... functions of these tissues in development of the neural tube and somites. Ectopic notochord induces floor plate and motor neuron development, whereas ablation leads to their loss (reviewed by Plazcek et al., 1993 ; Ruiz i Altaba and Jessel, 1993 ; Smith, 1994 ). Similarly, signals from notochord...

...+ levels in neurons during the periods of cell differentiation, axogenesis and synaptogenesis. * Author for correspondence at 2 Reprint requests to F.A.L. at 1 8 12 1995 © 1996 by Company of Biologists 1996 inositol trisphosphate receptor neuronal development intracellular...

... of Biologists 1995 Drosophila LIM domain neuronal development apterous homeodomain The LIM homeodomain genes encode a distinct family of proteins predicted to act as transcriptional regulators ( Freyd et al., 1990 ; Karlsson et al., 1990 ). One distinguishing feature of this gene family...

... to the same hormonal cues. neuronal development hormonal regulation neurobiology ecdysteroid 20-hydroxyecdysone neuronal death © 1993 by Company of Biologists 1993 19 08 1993 † Present address: Institute of Neuroscience, University of Oregon, Eugene, OR. 97403, USA...

... plasminogen activator mRNA is strongly expressed by many classes of neurons in peripheral and central nervous system. We have analysed its appearance in spinal cord and sensory ganglia, and found the mRNA is detectable by in situ hybridisation very early in neuronal development (by embryonic day 12.5...