...Clarisse Perron; Pascal Carme; Arnau Llobet Rosell; Eva Minnaert; Salomé Ruiz-Demoulin; Héloïse Szczkowski; Lukas Jakob Neukomm; Jean-Maurice Dura; Ana Boulanger ABSTRACT During animal development, neurons often form exuberant or inappropriate axons and dendrites at early stages, followed...

...-directed repair Knock-in Neuron Synaptobrevin Vamp Zebrafish The University of Edinburgh Medical Research Scotland http://dx.doi.org/10.13039/501100000294 ECG-1754-2021 Zebrafish ( Danio rerio ) are well suited for genetic manipulations ( Driever et al., 1996...

... and neurons that induced astrocyte ramifications and PAP formation. Co-cultured neurons were required for astrocyte ramifications in a neuronal activity-dependent manner, and synaptically-released glutamate and activation of astrocytic mGluR5 metabotropic glutamate receptor were likely involved in astrocyte...

... of bilaterian primary larvae. Here, we generated transcriptomes of the apical tissue in the sea anemone Nematostella vectensis and showed that it has a unique neuronal signature. By integrating previously published larval single-cell data with our apical transcriptomes, we discovered that the apical domain...

... ). Filopodial actin bundles are not necessary for microtubule advance into the peripheral domain of Aplysia neuronal growth cones . Nat. Cell Biol.   9 , 1360 - 1369 . 10.1038/ncb1655 Chen , K. , Yang , R. , Li , Y. , Zhou , J. C. and Zhang , M. ( 2020 ). Giant...

... responses that ensure animals develop properly. In water, the nervous system induces an adaptive response that reinforces vulval development through an unknown backup signal for vulval induction. This response involves the heterotrimeric G-protein EGL-30//G αq acting in motor neurons. It also requires body...

... interneurons in the cerebral cortex. Cortex GABAergic interneurons Migration Neuron Ministerio de Economía y Competitividad 10.13039/501100003329 RYC-2014-16410 SAF2017-89020-R Generalitat Valenciana 10.13039/501100003359 National Cancer Institute 10.13039...

...Shilpa Kaur; Pauline Mélénec; Sabrina Murgan; Guillaume Bordet; Pierre Recouvreux; Pierre-François Lenne; Vincent Bertrand ABSTRACT Wnt/β-catenin signalling has been implicated in the terminal asymmetric divisions of neuronal progenitors in vertebrates and invertebrates. However, the role of Wnt...

...Tomke Stürner; Anastasia Tatarnikova; Jan Mueller; Barbara Schaffran; Hermann Cuntz; Yun Zhang; Maria Nemethova; Sven Bogdan; Vic Small; Gaia Tavosanis ABSTRACT The formation of neuronal dendrite branches is fundamental for the wiring and function of the nervous system. Indeed, dendrite branching...

... and in vivo observations indicate that Trio is a master integrator for factors that guide axonal growth and cell migration, and coordinate telencephalic wiring. Trio GEF RhoA Neuron Migration Slit2 Axon guidance Rho GTPase Mouse Embryo Thalamocortical Corridor cells The small...

...Piero Sanfilippo; Peter Smibert; Hong Duan; Eric C. Lai Drosophila Elav is the founding member of the conserved family of Hu RNA-binding proteins (RBPs), which play crucial and diverse roles in post-transcriptional regulation. Elav has long served as the canonical neuronal marker. Surprisingly...

...Will J. McLean; Dalton T. McLean; Ruth Anne Eatock; Albert S. B. Edge Disorders of hearing and balance are most commonly associated with damage to cochlear and vestibular hair cells or neurons. Although these cells are not capable of spontaneous regeneration, progenitor cells in the hearing...

...Giacomo Masserdotti; Sergio Gascón; Magdalena Götz The key signalling pathways and transcriptional programmes that instruct neuronal diversity during development have largely been identified. In this Review, we discuss how this knowledge has been used to successfully reprogramme various cell types...

... cells into discrete populations of specialized adult cell types. In the spinal cord, neural progenitor cells are directed to differentiate into adult neurons through the action of mediators released from nearby organizing centers, such as the floor plate and paraxial mesoderm. These signals combine...

.... Activity Cre Neuron Notch1 Kidney The Notch signaling pathway is an evolutionarily conserved, short-range communication mechanism utilized throughout life in all metazoan species ( Artavanis-Tsakonas et al., 1999 ). The binding of a ligand to a Notch receptor triggers the unfolding...

... and VEGF 189 . VEGF 165 binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF 121 cannot activate NRP1-dependent neuronal responses. By contrast, the role of VEGF 189 in NRP1-mediated signalling pathways has not yet...

... describe a Spectrum of Fates approach that allows the identification of all the major neuronal subtypes in the zebrafish retina simultaneously. Spectrum of Fates is based on the combinatorial expression of differently coloured fluorescent proteins driven by the promoters of transcription factors...

...Tiago Ferreira; Yimiao Ou; Sally Li; Edward Giniger; Donald J. van Meyel The architectures of dendritic trees are crucial for the wiring and function of neuronal circuits because they determine coverage of receptive territories, as well as the nature and strength of sensory or synaptic inputs. Here...

... and evolutionary origin. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Brain development Cortex Evolution Human Neuron...

... cell self-renewal and differentiation; they divide asymmetrically to self-renew and generate the neurons and glia of the CNS. Here we report the identification of midlife crisis ( mdlc ; CG4973 ) as a gene required for the maintenance of neuronal differentiation and for neuroblast proliferation...