...Chika Akiba; Aya Takezawa; Yuanchang Tsai; Mire Hirose; Takumi Suzuki ABSTRACT The number of neural stem cells reflects the total number of neurons in the mature brain. As neural stem cells arise from neuroepithelial cells, the neuroepithelial cell population must be expanded to secure a sufficient...

... pathways, including the endo-lysosomal and autophagic pathways. Recent reports have suggested that lysosomes are essential for regulating neural stem cells in developing, adult and aged brains. However, the activity of these lysosomes has yet to be monitored in these brain tissues. Here, we report...

... extracellular matrix to maintain their undifferentiated state. Hindbrain boundaries Embryo Neural stem cells Progenitor cells RNA-sequencing Chondroitin-sulphate proteoglycan Extracellular matrix Israel Science Foundation http://dx.doi.org/10.13039/501100003977 1515/16 3332/21 1341/21...

...Christian Sigloch; Dominik Spitz; Wolfgang Driever ABSTRACT Neural proliferation zones mediate brain growth and employ Delta/Notch signaling and HES/Her transcription factors to balance neural stem cell (NSC) maintenance with the generation of progenitors and neurons. We investigated Notch...

... neural stem cells (NSCs) with unique properties and growth requirements. Adult NSCs constitute a reversibly quiescent cell population that can be activated by extracellular signals from the microenvironment in which they reside in vivo . Although genomic imprinting plays a role in adult neurogenesis...

...Paul M. Fox; Jocelyn L. Y. Tang; Andrea H. Brand ABSTRACT In the developing nervous system, neural stem cells (NSCs) use temporal patterning to generate a wide variety of different neuronal subtypes. In Drosophila , the temporal transcription factors, Hunchback, Kruppel, Pdm and Castor...

... cell-cycle events . Mol. Cell 64 , 362 - 375 . 10.1016/j.molcel.2016.09.018 Artegiani , B. , Lindemann , D. and Calegari , F. ( 2011 ). Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain . J. Exp. Med. 208...

...Srivathsa S. Magadi; Chrysanthi Voutyraki; Gerasimos Anagnostopoulos; Evanthia Zacharioudaki; Ioanna K. Poutakidou; Christina Efraimoglou; Margarita Stapountzi; Vasiliki Theodorou; Christoforos Nikolaou; Konstantinos A. Koumbanakis; John F. Fullard; Christos Delidakis ABSTRACT Neural stem cells...

...Maqsood Ahmed; Leandro N. Marziali; Ernest Arenas; M. Laura Feltri; Charles ffrench-Constant ABSTRACT Development of the central nervous system requires coordination of the proliferation and differentiation of neural stem cells. Here, we show that laminin alpha 2 (lm-α2) is a component...

...Kirsten Obernier; Arturo Alvarez-Buylla ABSTRACT In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young neurons for the olfactory bulb (OB) and hippocampus, respectively...

... the fast evolution of the human cortex. Cajal-Retzius cells Cortical folding Neural progenitors Neural stem cells Reelin Fonds de la Recherche Scientifique FNRS PDR T0002.13 FNRS PDR T00075.15 Interuniversity Poles of Attraction PAI p6/20 PAI7/20 WELBIO...

...Marcelo Boareto; Dagmar Iber; Verdon Taylor During embryonic and adult neurogenesis, neural stem cells (NSCs) generate the correct number and types of neurons in a temporospatial fashion. Control of NSC activity and fate is crucial for brain formation and homeostasis. Neurogenesis in the embryonic...

... . J. Cell. Biochem.   117 , 239 - 246 . 10.1002/jcb.25271 Le Belle , J. E. , Orozco , N. M. , Paucar , A. A. , Saxe , J. P. , Mottahedeh , J. , Pyle , A. D. , Wu , H. and Kornblum , H. I. ( 2011 ). Proliferative neural stem cells have high endogenous ROS...

...Alessandro Alunni; Laure Bally-Cuif In all vertebrate species studied thus far, the adult central nervous system harbors neural stem cells that sustain constitutive neurogenesis, as well as latent neural progenitors that can be awakened in lesional contexts. In spite of this common theme, many...

... specification Neural development Neural stem cells MicroRNA MicroRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional regulation of gene expression ( Bartel, 2004 ). A single miRNA can have up to several hundreds of target genes, and, so far, more than a thousand miRNAs have been...

...Naoki Watanabe; Ryoichiro Kageyama; Toshiyuki Ohtsuka In the developing mammalian brain, neural stem cells (NSCs) initially expand the progenitor pool by symmetric divisions. NSCs then shift from symmetric to asymmetric division and commence neurogenesis. Although the precise mechanisms regulating...

...Xing Zhou; Fang Liu; Miao Tian; Zhejun Xu; Qifei Liang; Chunyang Wang; Jiwen Li; Zhidong Liu; Ke Tang; Miao He; Zhengang Yang Neural stem cells (NSCs) persist in the adult mammalian subventricular zone (SVZ) of the lateral ventricle. Primary NSCs generate rapidly dividing intermediate progenitor...

...: Brain lesion in mice reveals a latent neurogenic potential in striatal astrocytes, which can proliferate and generate new neuroblasts. Neural stem cells Parenchymal progenitors Stem cell quiescence Lesion-induced neurogenesis Huntington's disease Mouse In adult neurogenic niches...

... interests The authors declare no competing financial interests. 17 1 2014 27 8 2014 © 2014. Published by The Company of Biologists Ltd 2014 Neural stem cells Parenchymal progenitors Postnatal neurogenesis Internal capsule Striatum Transient neurons In the mammalian...

.... * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Learning Neural stem cells Neurogenesis Plasticity The 2014 Keystone Symposium on Adult...