... in the wild-type tracked clones; (3) the cell fate at 45 hpf [progenitor (P) versus neuron (N)] by the relative position to the ventricle based on the method of Hevia et al. (2022) and immunostainings of neural progenitor (Sox2) and neuronal (HuC; Elavl3) markers performed at 45 hpf (Fig. S4A...

... (DHFR), a key enzyme in 1C metabolism, is highly expressed in human and mouse neural progenitors at the early stages of neocortical development. Here, we have investigated the role of DHFR in the developing neocortex and report that reducing its activity in human neural organoids and mouse embryonic...

... neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from the dorsal telencephalon, whereas inhibitory interneurons are generated in its ventral portion. The transcriptional regulator PRDM16 is expressed by radial glia, neural progenitors present in both...

... Boucherie , C. , Boutin , C. , Jossin , Y. , Schakman , O. , Goffinet , A. M. , Ris , L. , Gailly , P. and Tissir , F. (2017). Neural progenitor fate decision defects, cortical hypoplasia, and behavioral impairment in Celsr1-deficient mice . Mol. Psychiatry...

... signaling response, likely by modulating primary cilia. MicroRNA Polarity Hedgehog Neural progenitors Zebrafish Spatial and temporal information are integrated in developing nervous systems to produce a large array of distinct types of neurons and glia. In very broad terms, spatial cues...

... but is distinct from that seen in other ambulacraria, highlighting that deuterostomes employ diverse neurogenic mechanisms. Neurogenesis Neural specification SoxC SoxB2 Brn1/2/4 ELAV FGF Neural progenitors Neural precursors Deuterostomes Evolution Strongylocentrotus purpuratus Diverse...

...Robert N. Duncan; Yuanyuan Xie; Adam D. McPherson; Andrew V. Taibi; Joshua L. Bonkowsky; Adam D. Douglass; Richard I. Dorsky The vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neural progenitors. In zebrafish, a high level of postembryonic...

... system allows for such targeted mutagenesis, and we therefore tested it in combination with a piggyBac transposase lineage labeling system to track the development of neocortical neural progenitors with targeted mutations in genes linked to neurodevelopmental disruptions and tumor formation. We show...

... reflects an increase in the number of neocortical neurons, which is determined during development and primarily reflects the number of neurogenic divisions of distinct classes of neural progenitor cells. Consequently, the evolutionary expansion of the neocortex and the concomitant increase in the numbers...

... rise to neuroblasts that migrate via the RMS to the olfactory bulbs where they differentiate into interneurons. Neurogenesis Neural stem cells Neural progenitors Sp2 Cell cycle M phase Mouse © 2013. Published by The Company of Biologists Ltd 2013 15 11 2012 Competing...

... is specifically expressed in radial glia and SVZ neural progenitors during human brain development. Expression of GFAPδ in radial glia starts at around 13 weeks of pregnancy and disappears before birth. GFAPδ is continuously expressed in the SVZ progenitors at later gestational ages and in the postnatal brain. Co...

... activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors. These findings suggest that Lfng acts in a feedback loop downstream of proneural genes, which, by promoting Notch activation, maintains the sensitivity of progenitors to lateral inhibition...

... how heterogeneous the neural progenitor cells are, owing to dynamic changes in their nuclear position and gene expression. To address this issue, we systematically analyzed the cDNA profiles of a large number of single progenitor cells at the mid-embryonic stage in mouse. By cluster analysis...

...Levan Mchedlishvili; Hans H. Epperlein; Anja Telzerow; Elly M. Tanaka Complete regeneration of the spinal cord occurs after tail regeneration in urodele amphibians such as the axolotl. Little is known about how neural progenitor cells are recruited from the mature tail, how they populate...

... prolongs neural proliferation by maintaining a mitotically active neuroblast. In the abdomen, Grh terminates neural proliferation by regulating the competence of neuroblasts to undergo apoptosis in response to Abdominal-A expression. This study shows how a factor specific to late-stage neural progenitors...

...Ari A. Gershon; Jeremy Rudnick; Lobina Kalam; Kathryn Zimmerman ABSTRACT The development of the vertebrate nervous system depends upon striking a balance between differentiating neurons and neural progenitors in the early embryo. Our findings suggest that the homeodomain-containing gene Xdbx...

... of Biologists 1997 neurogenesis neural progenitors olfactory epithelium olfactory placodes olfactory receptor neurons bHLH proteins Mash1 NeuroD achaete-scute homolog atonal homolog mouse The process of neurogenesis in the nervous system of vertebrates produces a large variety...

... that the expression of CASH-1 may be important in defining a particular stage in the progenitor cell necessary for the differentiation of particular neuronal phenotypes. 20 December 1993 © 1994 by Company of Biologists 1994 retina neural progenitors achaete - scute homolog During...