... to the accessibility of this model, phagocytosis of migrating neural crest cells could be observed in real time for the first time in a mammalian model. We thus introduce a tractable in vitro model to study some of the key morphogenetic and cell type derivation events during early neural development. * Author...

... of dysfunctional cells on other developmental and metabolic features remains unclear. In addition, some studies identified that the expression level and timing of metabolic gene expression are reflective of endogenous human neural development ( Gordon et al., 2021 ). The discrepancies between studies may be due...

... the temporal cascade and neural stem cell competence in the embryonic central nervous system. Temporal patterning Neural development Neural stem cells Chronophage CTIP1/2 Bcl11a Bcl11b European Molecular Biology Organization http://dx.doi.org/10.13039/100004410 Wellcome Trust...

... neural development. By profiling the genome-wide dynamics of H3K9ac, H3K9cr and H3K18la in combination with ATAC and RNA sequencing, we reveal that these marks are tightly correlated with chromatin state and gene expression, and extensively involved in transcriptome remodeling to promote cell-fate...

.... E2A BHLH Neural development Pluripotent Summary: E2A is usually a permissive partner for instructive transcription factors. Expression and genome editing assays revealed that E2A goes it alone as a homodimer to dominantly impose neural identity on pluripotent cells. © 2020. Published...

.... To examine the effect of altered oscillatory dynamics of Hes1, we generated two types of Hes1 knock-in mice, a shortened (type-1) and an elongated (type-2) Hes1 gene, and examined their phenotypes focusing on neural development. Although both mutations affected Hes1 oscillations, the type-1 mutation dampened...

.... Cadherin FGF Neural development Pluripotent Wnt Mouse There is an increasing appreciation that changes in adhesion and morphology help to regulate cell fate changes ( Gilmour et al., 2017 ). The homotypic adhesion molecule E-cadherin (also known as cadherin 1) is expressed on the surface...

... and their associated gene expression profiles, identifying co-regulated genes that mediate a temporal programme of neuronal subtype specification. Spinal cord Neural development Neural tube ScRNA-seq Single cell transcriptomics European Research Council 10.13039/100010663 742138 Human...

... work is properly attributed. Summary: RNA interference identifies SoxN and Sox102F as key regulators of the morphological properties of a neuronal type of the fruit fly visual system that computes the direction of motion. Neural development Layer specificity Optic lobe Drosophila...

... of Biologists on ‘Thinking beyond the dish: taking in vitro neural differentiation to the next level’, highlighting the limitations and potential applications of organoid-based technologies. Neural development Organoids In vitro Neural differentiation Developmental biology aims...

... attributed. Summary: This Review discusses how crosstalk between different families of axon guidance receptors and cues functions during axonal navigation, highlighting recent studies that question the textbook model of axon guidance. Axon guidance Guidance cues Neural development Local...

.... bHLH gene Neural development Neurogenesis Neuronal diversity Proneural gene The function of the nervous system relies on a large number of neurons with diverse functions. Even the simple nervous system of the nematode C. elegans has more than 100 classes of neurons, and this number...

... with abnormal axon innervation and defective peristalsis of the midgut. Neural development Enteric nervous system Ret signaling GDNF signaling Axon branching Drosophila The RET (rearranged during transfection) receptor tyrosine kinase is the leading susceptibility locus for Hirschsprung's...

... throughout the pancreas. A screen of pancreatic extracellular signals identified factors that stimulated islet cell development. These included semaphorin 3a, a guidance cue in neural development without known functions in the pancreas. In the fetal pancreas, peripheral mesenchymal cells expressed Sema3a...

... circuit Neural development E/I balance National Institute of Neurological Disorders and Stroke 10.13039/100000065 R01NS064263 F31NS076326 National Institute on Drug Abuse 10.13039/100000026 F31DA038399 Neurons in the brain are organized into circuits...

... that terminates G2 phase arrest and promotes neural development might be extrinsic to the pI cell. An appealing candidate for an extrinsic signal would be the steroid hormone ecdysone, because pI cell division in the microchaetae lineage roughly coincides with a minor peak in ecdysone expression ( Truman et al...

... by The Company of Biologists Ltd 2015 Summary: Unbiased functional genomics approaches reveal that Nkx2.2, Nkx6.1 and Olig2 directly repress multiple alternative fates during mammalian neural progenitor fate specification. Transcriptional regulation Fate specification Neural development Mouse...

..., such as disease modeling and cell therapy, their potential usefulness as a tool in basic developmental biology had remained less clear. From the data discussed here, PSC-derived models of neural development have the potential to do much more than just extend the findings previously obtained in animal models...

..., suggesting that they contribute to establishing regional identity. Cell specification Neural development Neural stem cells MicroRNA MicroRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional regulation of gene expression ( Bartel, 2004 ). A single miRNA can have up...