... fiber growth into the gut is unknown. In vertebrates, CXCR4, a cell-surface receptor for the CXCL12 chemokine, regulates migration of neural crest cells and axon pathfinding. We have employed chimeric tissue recombinations and organ culture assays to study the role of CXCR4 and CXCL12 molecules...

... distinct and require DUSP6-mediated signaling for their migration. Enteric nervous system Neural crest cells Wavefront Hindgut Hirschsprung disease National Institutes of Health R01DK103785 R21HD106036 R21HD106036 F32DK121440 Innovációs és Technológiai...

...) patterning. Moreover, maturation of the neural tube organoids showed the emergence of multipotent neural crest cells and mature neurons. Single-cell transcriptome analyses revealed the sequence of transcriptional events in the emergence of neural crest cells and neural differentiation. Thanks...

... . 10.1074/jbc.M112.349274 Chen , Y. , Wang , Z. , Chen , Y. and Zhang , Y. ( 2019 ). Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice . Cell Tissue Res. 376 , 199 - 210 . 10.1007/s00441-018-2944-5 Claes , P...

...Nandor Nagy; Tamas Kovacs; Rhian Stavely; Viktoria Halasy; Adam Soos; Emoke Szocs; Ryo Hotta; Hannah Graham; Allan M. Goldstein ABSTRACT The enteric nervous system (ENS), which is derived from enteric neural crest cells (ENCCs), represents the neuronal innervation of the intestine. Compromised ENCC...

... pluripotent cranial neural crest cells and differentiate with distinct developmental timing and cellular morphologies. The mechanisms that divide neural crest cells into discrete populations are not fully understood. Here, we use single-cell RNA sequencing to transcriptomically define different populations...

... musculoskeletal and connective tissues. We demonstrate that CPM contributes to medial pharyngeal skeletal and connective tissues associated with both branchiomeric and somite-derived neck muscles. CPM and neural crest cells (NCC) make complementary mediolateral contributions to pharyngeal structures...

...Nandor Nagy; Csilla Barad; Ryo Hotta; Sukhada Bhave; Emily Arciero; David Dora; Allan M. Goldstein ABSTRACT The enteric nervous system (ENS) arises from neural crest cells that migrate, proliferate, and differentiate into enteric neurons and glia within the intestinal wall. Many extracellular...

.... During the hypoxic stage, a large number of neural crest cells arise from the head neural tube by epithelial-to-mesenchymal transition (EMT). As EMT-like cancer dissemination can be promoted by hypoxia, we investigated whether hypoxia contributes to embryonic EMT. Using chick embryos, we show...

... that affects the NNE and neural crest cells. The resulting loss of NNE integrity contributes to an inability of the cranial neural folds to move toward the midline and results in NTD. Further, we identified Esrp1 , Sostdc1 , Fermt1 , Tmprss2 and Lamc2 as novel NNE-expressed genes that are downregulated...

... differentiation. ERK pathway Cleft palate Glossoptosis Micrognathia Mandibular asymmetry Pierre Robin sequence Neural crest cells The ERK transduction pathway is one of the signaling cascades that facilitates the transmission of extracellular signals to cytoplasmic and nuclear effectors...

... no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Neural crest cells Epithelium-to-mesenchyme transition Cell migration Chemotaxis Contact-inhibition of locomotion Cancer Neurocristopathies The neural crest (NC) is a multipotent stem cell...

... ear and CVG. Non-autonomous cell signaling from the hindbrain to the OV is required for inner ear morphogenesis and neurogenesis. In this study, we show that neuroepithelial cells (NECs), including neural crest cells (NCCs), can contribute directly to the OV from the neural tube. Using Wnt1-Cre, Pax3...

... to further investigate the role of 5-HT2B in embryogenesis, focusing on craniofacial development. By means of gene gain- and loss-of-function approaches and tissue transplantation assays, we demonstrated that 5-HT2B modulates, in a cell-autonomous manner, postmigratory skeletogenic cranial neural crest cell...

...Noah R. Druckenbrod; Miles L. Epstein The enteric nervous system (ENS) develops from neural crest cells (NCCs)that enter the foregut and hindgut to become enteric neural-crest-derived cells (ENCCs). When these cells of neural crest origin fail to colonize the terminal hindgut, this aganglionic...

...Maryline Minoux; Gregory S. Antonarakis; Marie Kmita; Denis Duboule; Filippo M. Rijli In vertebrates, face and throat structures, such as jaw, hyoid and thyroid cartilages develop from a rostrocaudal metameric series of pharyngeal arches,colonized by cranial neural crest cells (NCCs). Colinear Hox...

...Yoshiaki Okamura; Yumiko Saga Notch signaling is involved in neurogenesis, including that of the peripheral nervous system as derived from neural crest cells (NCCs). However,it remains unclear which step is regulated by this signaling. To address this question, we took advantage of the Cre-loxP...

...,differentiation and apoptosis. We have generated mice with a neural crest cell-specific deletion of the β1-integrin gene to analyse the role ofβ1-integrins in neural crest cell migration and differentiation. This targeted mutation caused death within a month of birth. The loss ofβ1-integrins from the embryo...

...Alan J. Burns; Jean-Marie M. Delalande; Nicole M. Le Douarin The enteric nervous system (ENS) is derived from vagal and sacral neural crest cells (NCC). Within the embryonic avian gut, vagal NCC migrate in a rostrocaudal direction to form the majority of neurons and glia along the entire length...

...Jon P. Golding; Monica Dixon; Martin Gassmann Within the developing vertebrate head, neural crest cells (NCCs) migrate from the dorsal surface of the hindbrain into the mesenchyme adjacent to rhombomeres (r)1 plus r2, r4 and r6 in three segregated streams. NCCs do not enter the intervening...