...Andrea R. Yung; Allison M. Nishitani; Lisa V. Goodrich Netrin 1 (Ntn1) is a multifunctional guidance cue expressed in the ventricular zone and floor plate of the embryonic neural tube. Although Ntn1 is best known for acting as an axon guidance cue through Dcc and neogenin receptors, it is also...

... netrin 1 (NTN1) as a key factor upregulated within the SVZ after demyelination and involved in local angiogenesis and progenitor cell migration. Blocking NTN1 expression using a neutralizing antibody inhibited both lesion-induced vascular reactivity and progenitor cell recruitment at the lesion site. We...

... their axons terminate close to motor neurons. We show that the growth of EN1 axons along a ventrolateral pathway toward motor neurons is dependent on netrin-1 signaling. In addition, we demonstrate that En1 regulates pathfinding and fasciculation during the second phase of EN1 axon growth in the ventrolateral...

... organized in Gli2 −/− mutants. * Author for correspondence (e-mail: [email protected] ) 09 06 1999 19 04 1999 © 1999 by Company of Biologists 1999 Gli2 Floor plate Cell adhesion molecule Nr-CAM TAG-1 Netrin-1 Mouse Dbx1 The floor plate has also been...

... in ventral thalamus is correspondingly reduced and the normally graded expression of RPTP δ in that domain is no longer apparent. In ventral telencephalon, a domain characterized in the wild type by Netrin-1 and Nkx-2 . 1 expression and by retrogradely labeled neurons is absent in the mutant. Defects in TCA...

... in the lateral GE and the sulcus between the lateral and medial ridges of the GE (ISS), as well as evidence implicating the axonal chemoattractant netrin-1 in mediating these effects. Explants of lateral GE and ISS obtained from E12.5 and E13.5 mouse forebrain have a strong effect on both the outgrowth...