... for the model to reproduce the experimentally observed sensitivity. * Author for correspondence (e-mail: [email protected]) 5 8 2005 ©2005. 2005 Axon guidance Chemotaxis Computational model Nerve growth factor Dorsal root ganglion Axons use many types of navigational cues...

... Nerve growth factor. Neurotrophin-3 was also found to be necessary for dermatome dissociation using in vitro explants or partially dissociated dermomyotomes. The functional relevance of these observations was investigated by neutralizing endogenous Neurotrophin-3 using a specific blocking antibody...

...Vladimir L. Buchman; Michael Sporn; Alun M. Davies ABSTRACT We have investigated if transforming growth factor-beta (TGF-β) isoforms influence the level of expression of nerve growth factor (NGF) mRNA and neurotrophin-3 (NT-3) mRNA in embryonic tissues innervated by neurons that depend on NGF...

... development. 23 08 1993 © 1993 by Company of Biologists 1993 mouse neurotrophin mRNA nerve growth factor sensory neuron A family of small homodimeric proteins termed neurotrophins plays a key role in the development of the vertebrate nervous system. Some of the most extensive...

... antibody (mAb). Some neurites whose outgrowth was induced by nerve growth factor (NGF) were c- kit -positive, but anti-NGF mAb did not inhibit the rmSCF-induced neurite outgrowth. rmSCF did not induce neurite outgrowth from DRGs of W / W embryos that did not express c- kit receptors on the cell surface...

...Vladimir L. Buchman; Alun M. Davies ABSTRACT To investigate if different neurotrophins regulate the survival of neurons at successive developmental stages, we studied the effect of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neu-rotrophin-3 (NT-3) on the survival...

... Research, Nine Cambridge Center and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA 04 01 1993 © 1993 by Company of Biologists 1993 nerve growth factor brain-derived neurotrophic factor neurotrophin-3 in situ hybridization...

...Mark Murphy; Kate Reid; Melissa A. Brown; Perry F. Bartlett ABSTRACT Leukemia inhibitory factor (LIF) was recently shown to stimulate the generation of sensory neurons from the murine neural crest in vitro. Here, we examine the respective activities of LIF and nerve growth factor (NGF) throughout...

...Alfredo Rodriguez-Tébar; Hermann Rohrer ABSTRACT An important step in the development of peripheral sensory and sympathetic neurons is the onset of the survival response and dependence on the presence of nerve growth factor (NGF) or other neurotrophic factors. We have recently observed...

...Mark A. Watson; Jeffrey Milbrandt NGFI-A and NGFI-B are two genes that are induced in PC 12 cells treated with nerve growth factor and encode zinc-finger proteins that may act as transcription factors. To study the function of these genes in vivo , their expression in rat embryos and postnatally...

.... The site and timing of nerve growth factor (NGF) synthesis and NGF receptor expression have been elucidated, thereby clarifying the role of this neurotrophic factor in development. A novel concept in neurotrophic factor physiology has emerged: the survival of neurones that innervate two separate target...

...Hermann Rohrer; Magdalena Hofer; Rainer Hellweg; Sigrun Korsching; August D. Stehle; Siawusch Saadat; Hans Thoenen The monoclonal antibody 27/21 directed against mouse nerve growth factor (NGF) interferes in vivo with the survival of sensory dorsal root ganglion (DRG) neurones during...

...Brigitte Raynaud; Nicole Faucon-Biguet; Simone Vidal; Jacques Mallet; Michel J. Weber The survival of new-born rat sympathetic neurones in culture was increased in a dose-dependent manner by 7S nerve growth factor (NGF). NGF also increased, in a parallel manner, the specific activities of tyrosine...

...Ted Ebendal; Håkan Persson Nerve growth factor (β NGF) is a protein supporting sympathetic and sensory innervation in the peripheral tissues as well as cholinergic innervation in the brain. A DNA probe derived from a genomic clone coding for chicken NGF was used to study NGF mRNA levels during...

...Patrick Doherty; Derek A. Mann; Frank S. Walsh ABSTRACT The growth of PC 12 cells on a collagen substratum or on monolayers of several non-neuronal cell types was studied by measuring nerve growth factor (NGF)- dependent increases in the expression of a 150 × 10 3 (M r) neurofilament protein...